Evidence map›Paper›PMID 34442304›Full record

ReviewInsects2021

Cell Line Platforms Support Research into Arthropod Immunity.

Cynthia L Goodman, David S Kang, David Stanley

Open access · goldAbstract readReview
In one paragraph

Review in Insects, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Frontiers in immunology · 2023
    Article
  8. Article
  9. A database of crop pest cell lines.In vitro cellular & developmental biology. Animal · 2022
    Article
  10. In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials.International journal of environmental research and public health · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cynthia L GoodmanBiological Control of Insects Research Laboratory, USDA/Agricultural Research Service, 1503 S. Providence Rd., Columbia, MO 65203, USA.ORCID 0000-0001-6631-9848
David S KangBiological Control of Insects Research Laboratory, USDA/Agricultural Research Service, 1503 S. Providence Rd., Columbia, MO 65203, USA.ORCID 0000-0002-5568-7140
David StanleyBiological Control of Insects Research Laboratory, USDA/Agricultural Research Service, 1503 S. Providence Rd., Columbia, MO 65203, USA.ORCID 0000-0003-0248-9914
Agricultural Research Service · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate immune responses are essential to maintaining insect and tick health and are the primary defense against pathogenic viruses, bacteria, and fungi. Cell line research is a powerful method for understanding how invertebrates mount defenses against pathogenic organisms and testing hypotheses on how these responses occur. In particular, immortal arthropod cell lines are valuable tools, providing a tractable, high-throughput, cost-effective, and consistent platform to investigate the mechanisms underpinning insect and tick immune responses. The research results inform the controls of medically and agriculturally important insects and ticks. This review presents several examples of how cell lines have facilitated research into multiple aspects of the invertebrate immune response to pathogens and other foreign agents, as well as comments on possible future research directions in these robust systems.

Indexed as

antimicrobial peptideantiviraleicosanoidhemocyteIMDinnate immunitylysozymepathogenRNAisignaling pathwayToll

Identifiers

PMID34442304
PMCPMC8397109
OpenAlexW3193574006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.