ReviewJournal of clinical medicine2021
Clinical Implications of Growth Hormone Deficiency for Oral Health in Children: A Systematic Review.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Comparative effectiveness of cervical vertebral maturation and hand-wrist radiography in assessing bone age in patients with amelogenesis imperfecta: a retrospective analysis.BMC oral health · 2026Article
- Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients.Frontiers in pediatrics · 2026Article
- Variability in Permanent Teeth Eruption in Children with Growth Hormone Deficiency and Idiopathic Short Stature.Journal of clinical medicine · 2025Article
- Polymorphisms and dental age in non-syndromic cleft lip and palate: a cross-sectional study.BMC pediatrics · 2025Article
- Article
- Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical Differences.Biomedicines · 2024Article
- Metabolic Bone Diseases Affecting Tooth Eruption: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Comprehensive Oral Diagnosis and Management for Women with Turner Syndrome.Diagnostics (Basel, Switzerland) · 2024Article
- Vertical changes in the hard tissues after space closure by miniscrew sliding mechanics: a three-dimensional modality analysis.Head & face medicine · 2023Article
- Developmental enamel defects and dental anomalies of number and size in children with growth hormone deficiency.Scientific reports · 2023Article
- Functional orthopedic treatment combined with differential-force technique to treat a severe mandibular retraction with growth-hormone deficiency: a case report.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Skeletal and dental age discrepancy and occlusal traits in children with growth hormone deficiency and idiopathic short stature.Clinical oral investigations · 2022Article
- Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical Implications of Growth Hormone Deficiency for Oral Health in Children: A Systematic Review.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth hormone (GH) is involved in the regulation of the postnatal dental and skeletal growth, but its effects on oral health have not been clearly defined. This paper aims to provide a review of current clinical knowledge of dental caries, tooth wear, developmental enamel defects, craniofacial growth and morphology, dental maturation, and tooth eruption in growth hormone deficient (GHD) children. A systematic review was carried out using Scopus, MEDLINE-EbscoHost and Web of Science from 2000 to May 2021. PRISMA guidelines for reporting systematic reviews were followed. All the selected studies involved groups under eighteen years of age, covering a total of 465 GHD patients. The studies that were selected provide reliable evidence for delayed dental maturity and orthodontic disturbances in GHD patients. Data on dental hard tissues pathology are scarce and are limited to occurrences of dental caries. GHD children showed abnormal craniofacial morphology with reduced mandibular dimensions, with a resulting tendency towards Angle's Class II occlusion, which affected up to 31% of patients. Dental age has been shown to be delayed in GHD patients by about 1 to 2 years. Moreover, the risk of dental caries in children with GHD decreases with increasing levels of vitamin D. Hence, further studies would be valuable for evaluating the risk of various oral health problems and to organize targeted dental care for this vulnerable group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.