ArticleJournal of clinical medicine2021
Value of Left Ventricular Feature Tracking Strain Analysis for Detection of Early Cardiac Involvement in Fabry Disease (FD).
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Interpreting a Thick Myocardium on Cardiac MR: A Practical Guide for Radiologists.Journal of the Korean Society of Radiology · 2026Review
- Contemporary Multimodality Imaging for Diagnosis and Management of Fabry Cardiomyopathy.Journal of clinical medicine · 2024Review
- Left Ventricular Deformation and Rotational Mechanics in Various Pathologies-The Role of the Pattern of Abnormalities.Journal of clinical medicine · 2023Article
- Treatment of Fabry Disease: Established and Emerging Therapies.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features.Diagnostics (Basel, Switzerland) · 2022Review
- Cardiac MRI in Fabry disease.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
7 authors.
Funding
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Abstract
purposeDetection of cardiac involvement in Fabry disease (FD) is of high importance for treatment management. Native T1 mapping especially showed great potential for detection of early cardiac manifestations. Echocardiographic studies showed strain abnormalities in FD patients, but data on MRI feature tracking strain analysis (FT-SA) is limited. Therefore, the aim of our study was to evaluate the potential of FT-SA compared to native T1 and the FD specific biomarker Globotriaosylsphingosine (LysoGb3).
methods28 consecutive FD patients (18 female; 47.8 years ± 17.4 standard deviation (SD)) and 28 control subjects (18 female; 46.6 years ± 18.2 SD) underwent cardiac MRI at 1.5 Tesla. Global native T1 times and left ventricular FT-SA were evaluated. Results were correlated to serum Lyso-Gb3-levels.
resultsNative T1 times, global longitudinal (GLS) and global radial strain (GRS) were significantly reduced in FD patients (
conclusionsNative T1 times and strain values differ significantly between FD patients and control subjects and showed promising correlations to the FD specific biomarker LysoGb3. We therefore conclude that strain abnormalities occur early beside native T1 reductions in cardiac FD involvement. Large scale trials are needed to verify our findings.
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