Evidence map›Paper›PMID 34441965›Full record

ArticleJournal of clinical medicine2021

Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer.

Charlotte Eitel, Vanessa Sciacca, Nina Bartels, Roza Saraei, Thomas Fink, Ahmad Keelani, André Gaßmann, Karl-Heinz Kuck, Julia Vogler, Christian-Hendrik Heeger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Catheter ablation in patients with atrial fibrillation and cancer: a systematic review and updated meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Pooled it
  2. Safety and efficacy of catheter ablation for atrial fibrillation in cancer survivors: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
  3. Contemporary management of atrial fibrillation in patients with cancer-the 2025 European Heart Rhythm Association survey.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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  10. Outcomes and readmissions in patients with cancer undergoing catheter ablation for atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Charlotte EitelDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.ORCID 0000-0002-8733-6791
Vanessa SciaccaDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Nina BartelsDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Roza SaraeiDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Thomas FinkDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Ahmad KeelaniDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
André GaßmannDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Karl-Heinz KuckDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Julia VoglerDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
Christian-Hendrik HeegerDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.ORCID 0000-0002-9014-8097
Roland Richard TilzDepartment of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein-Campus, 23562 Lübeck, Germany.
University Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA growing body of evidence suggests a strong association between atrial fibrillation (AF) and cancer. A relevant number of patients with a present or former malignant disease with highly symptomatic drug-refractory AF are in need of interventional therapy. Data on the safety and efficacy of catheter ablation in these patients are sparse. The present study aims to analyze the safety and efficacy of cryoballoon-based pulmonary vein isolation (CB-PVI) for symptomatic AF in patients with past or present cancer disease. METHODS AND

resultsConsecutive patients undergoing CB-PVI for symptomatic AF at University Hospital Lübeck, Germany between July 2015 and January 2019 were included in this study. Propensity-score based matching was performed to identify comparable patients with and without cancer disease and further analyze clinical characteristics, periprocedural complications and arrhythmia-free survival. A total of 70 patients with a history of cancer undergoing CB-PVI were matched to 70 patients without a history of cancer. The frequency of complications was similar between patients with and without a history of cancer (

conclusionThis study indicates that CB-PVI for symptomatic AF is equally safe and effective in patients with and without a history of cancer and cancer treatment.

Indexed as

atrial fibrillationcancercardiooncologycryoballoon ablationmalignomapulmonary vein isolation

Identifiers

PMID34441965
PMCPMC8397043
OpenAlexW3194602026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.