Evidence map›Paper›PMID 34441929›Full record

ArticleJournal of clinical medicine2021

Clinical Characteristics and Outcomes of Adults with Nephrotic Syndrome Due to Minimal Change Disease.

Sophia Lionaki, Evangelos Mantios, Ioanna Tsoumbou, Smaragdi Marinaki, George Makris, George Liapis, Chrysovalantis Vergandis, Ioannis Boletis

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophia LionakiDepartment of Nephrology & Transplantation, Laiko Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece.ORCID 0000-0003-1643-8923
Evangelos MantiosDepartment of Nephrology & Transplantation, Laiko Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece.
Ioanna TsoumbouDepartment of Nephrology & Transplantation, Laiko Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece.
Smaragdi MarinakiDepartment of Nephrology & Transplantation, Laiko Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece.
George MakrisDepartment of Nephrology & Transplantation, Laiko Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece.ORCID 0000-0001-8392-5532
George LiapisDepartment of Pathology, Laiko Hospital, 115 27 Athens, Greece.
Chrysovalantis VergandisDepartment of Radiology, Laiko Hospital, 115 27 Athens, Greece.
Ioannis BoletisDepartment of Nephrology & Transplantation, Laiko Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMinimal change disease (MCD) is considered a relatively benign glomerulopathy, as it rarely progresses to end-stage kidney disease. The aim of this study was to describe the characteristics and outcomes of adults with MCD and identify potential risk factors for relapse. PATIENTS &

methodsWe retrospectively studied a cohort of adults with biopsy-proven MCD in terms of clinical features and treatment outcomes. Baseline characteristics and outcomes were recorded and predictors of relapse were analyzed using logistic regression multivariate analysis.

results59 patients with adult-onset primary MCD with nephrotic syndrome were included. Mean serum creatinine at diagnosis was 0.8 mg/dL (±2.5) and estimated GFR (eGFR) was 87 mL/min/1.73 m

conclusionIn this series of patients, almost 46% of adult-onset nephrotic MCD patients experienced a relapse, although their renal progression was rare. Younger onset age was an independent risk factor for relapse in adult-onset MCD patients.

Indexed as

adultsminimal change diseasenephrotic syndrome

Identifiers

PMID34441929
PMCPMC8397036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.