Evidence map›Paper›PMID 34441908›Full record

ArticleJournal of clinical medicine2021

Hyperprolactinemia in Adults with Prader-Willi Syndrome.

Anna Sjöström, Karlijn Pellikaan, Henrik Sjöström, Anthony P Goldstone, Graziano Grugni, Antonino Crinò, Laura C G De Graaff, Charlotte Höybye

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Anna SjöströmDepartment of Clinical Chemistry, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Karlijn PellikaanInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-0738-0275
Henrik SjöströmDepartment of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden.
Anthony P GoldstonePsychoNeuroEndocrinology Research Group, Centre for Neuropsychopharmacology, Division of Psychiatry, Department of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Graziano GrugniInternational Network for Research, Management and Education on Adults with PWS.ORCID 0000-0003-4708-2544
Antonino CrinòInternational Network for Research, Management and Education on Adults with PWS.ORCID 0000-0003-3548-7114
Laura C G De GraaffInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.
Charlotte HöybyeDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-3980-1927
Erasmus MC · NLKarolinska University Hospital · SEBambino Gesù Children's Hospital · ITImperial College Healthcare NHS Trust · GBIRCCS Istituto Auxologico Italiano · ITKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder typically characterized by body composition abnormalities, hyperphagia, behavioural challenges, cognitive dysfunction, and hypogonadism. Psychotic illness is common, particularly in patients with maternal uniparental disomy (mUPD), and antipsychotic medications can result in hyperprolactinemia. Information about hyperprolactinemia and its potential clinical consequences in PWS is sparse. Here, we present data from an international, observational study of 45 adults with PWS and hyperprolactinemia. Estimated prevalence of hyperprolactinemia in a subset of centres with available data was 22%, with 66% of those related to medication and 55% due to antipsychotics. Thirty-three patients were men, 12 women. Median age was 29 years, median BMI 29.8 kg/m

Indexed as

adultshyperprolactinemiahypogonadismPrader-Willi syndrome

Identifiers

PMID34441908
PMCPMC8396901
OpenAlexW3193878322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.