Evidence map›Paper›PMID 34441891›Full record

ArticleJournal of clinical medicine2021

Severe Lymphopenia as a Predictor of COVID-19 Mortality in Immunosuppressed Patients.

María Martínez-Urbistondo, Ángela Gutiérrez-Rojas, Ane Andrés, Isabel Gutiérrez, Gabriela Escudero, Sonia García, Andrea Gutiérrez, Enrique Sánchez, Jesús Herráiz, Sara De La Fuente and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Influence of chronic use of corticosteroids and calcineurin inhibitors on COVID-19 clinical outcomes: analysis of a nationwide registry.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

María Martínez-UrbistondoInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Ángela Gutiérrez-RojasInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Ane AndrésInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Isabel GutiérrezInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Gabriela EscuderoInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Sonia GarcíaInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.ORCID 0000-0003-1562-5567
Andrea GutiérrezInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Enrique SánchezInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Jesús HerráizInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Sara De La FuenteInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Alejandro CallejasInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Carmen De MendozaInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.
Víctor Moreno-TorresInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.ORCID 0000-0002-9798-4514
Hospital Universitario Puerta de Hierro Majadahonda · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) has a high mortality in certain group of patients. We analysed the impact of baseline immunosuppression in COVID-19 mortality and the role of severe lymphopenia in immunocompromised subjects.

methodsWe analysed all patients admitted with COVID-19 in a tertiary hospital in Madrid between March 1st and April 30th 2020. Epidemiological and clinical data, including severe lymphopenia (<500 lymphocytes/mm

resultsA total of 1594 patients with COVID-19 pneumonia were hospitalised during the study period. 166 (10.4%) were immunosuppressed. Immunocompromised patients were younger (64 vs. 67 years,

conclusionImmunosuppression is an independent mortality risk factor in COVID-19. Severe lymphopenia should be promptly identified in these patients.

Indexed as

COVID-19immunosuppressionsevere lymphopenia

Identifiers

PMID34441891
PMCPMC8396991
OpenAlexW3195957169

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.