ArticleJournal of clinical medicine2021
Examining the Neurobiology of Non-Suicidal Self-Injury in Children and Adolescents: The Role of Reward Responsivity.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- A meta-analysis of influencing factors of non-suicidal self-injury behavior in adolescents with depression.Frontiers in psychiatry · 2026Pooled it
- Scars, screens, and stakes: Link between non-suicidal self-injury and problem gambling, problem gaming, and problematic internet use - A systematic review.Journal of behavioral addictions · 2025Pooled it
- The Role of Glymphatic Clearance in Affective Decision-Making in Adolescents with Non-Suicidal Self-Injury.CNS neuroscience & therapeutics · 2026Article
- Who Gets by with Help from Friends? Multilevel Associations Between Loneliness, Friend Support, and Emotion Regulation in Adolescents with and Without Self-Injury.Social development (Oxford, England) · 2026Article
- Non-suicidal self-injury and digital ostracism: a novel smartphone-based paradigm capturing real-time responses to social media exclusion.Borderline personality disorder and emotion dysregulation · 2026Article
- Longitudinal changes in amygdala-supplementary motor area connectivity and their association with recurrent self-harm in adolescents with mood disorders.BMC psychiatry · 2026Article
- Decreased anticipatory and consummatory pleasure in adolescents with non-suicidal self-injury and its association with suicidal attempt.Child and adolescent psychiatry and mental health · 2026Article
- Beyond distress relief: the Anhedonic Subtype of nonsuicidal self-injury and the imperative for Positive Affect Treatment.Frontiers in psychiatry · 2026Article
- Cortical dysfunction and impulsivity in non-suicidal self-injury: a multimodal study using TMS-EEG and fNIRS.Annals of medicine · 2025Article
- Neural mechanisms and neuromodulation therapies for non-suicidal self-injury.Molecular psychiatry · 2025Review
- The possible effect of inflammation on non-suicidal self-injury in adolescents with depression: a mediator of connectivity within corticostriatal reward circuitry.European child & adolescent psychiatry · 2025Article
- A national survey of suicidality and non-suicidal self-injury in bipolar disorder: insights from network analysis.BMC psychiatry · 2025Article
- Resting-state spontaneous brain activity as a neural marker for suicidal ideation in adolescents with non-suicidal self-injury: a voxel-wise and machine learning study.Frontiers in psychiatry · 2025Article
- Temperament and the Experience of Tension and Self-Injurious Behaviour in Adolescents-The Mediating Role of Maladaptive Perfectionism.Brain sciences · 2024Article
- Prevalence of Adverse Childhood Experiences and Their Associations with Non-Suicidal Self-Injury Among Chinese Adolescents with Depression.Child psychiatry and human development · 2024Article
- Reward responsivity and habit formation in the co-occurrence of restrictive eating and nonsuicidal self-injury.Journal of psychiatric research · 2024Article
- Transdiagnostic Correlates of Nonsuicidal Self-Injury: The Roles of Anhedonia, Repetitive Negative Thinking, and Trait Mindfulness.Journal of psychopathology and behavioral assessment · 2024Article
- Non-suicidal self-injury in Chinese population: a scoping review of prevalence, method, risk factors and preventive interventions.The Lancet regional health. Western Pacific · 2023Article
- [Advances in the electrophysiological research on neurocognitive function in adolescents with non-suicidal self-injury].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review.General psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although prior work has shown heightened response to negative outcomes and reduced response to positive outcomes in youth with a history of non-suicidal self-injury (NSSI), little is known about the neural processes underlying these responses. Thus, this study examined associations between NSSI engagement and functional activation in specific regions of interest (ROIs) and whole-brain connectivity between striatal, frontal, and limbic region seeds during monetary and social reward tasks. To test for specificity of the influence of NSSI, analyses were conducted with and without depressive symptoms as a covariate. We found that NSSI was associated with decreased activation following monetary gains in all ROIs, even after controlling for depressive symptoms. Exploratory connectivity analyses found that NSSI was associated with differential connectivity between regions including the DS, vmPFC, insula, and parietal operculum cortex when controlling for depressive symptoms. Disrupted connectivity between these regions could suggest altered inhibitory control of emotions and pain processing in individuals with NSSI. Findings suggest dysfunctional reward processes in youth with NSSI, even very early in the course of the behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.