ReviewJournal of clinical medicine2021
Insights into the Cellular and Molecular Mechanisms That Govern the Fracture-Healing Process: A Narrative Review.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of Osteoking on fracture healing: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Article
- Moth-Eaten Osteolysis of Multiple Foot Bones After a Conservatively Treated "Stable" Ankle Fracture: A Case Report and Literature Review.Clinical case reports · 2026Article
- Evaluation of effectiveness and safety of polaprezinc as an adjuvant therapy in enhancing fracture healing in adults with closed fractures: a prospective study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Laser-Based Photobiomodulation in Postoperative Tissue Healing in Oral and Maxillofacial Surgery: Systematic Review of RCTs.Journal of clinical medicine · 2026Review
- Traumatic dorsolateral diaphragmatic hernia in a juvenile raccoon dog (Nyctereutes viverrinus viverrinus).The Journal of veterinary medical science · 2026Article
- Development of a gene-activated matrix for enhanced AAV gene deliveryFrontiers in bioengineering and biotechnology · 2026Article
- The Effects and Mechanisms of Low-Intensity Pulsed Ultrasound on Bone Remodeling: From Laboratory to Clinic.Biomolecules · 2025Review
- Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A material dynamically enhancing both load-bearing and energy dissipation capability under cyclic loading.Science advances · 2025Article
- Deer antler velvet (Cervus elaphus sibiricus) promotes fracture healing via partial BMP2-Smad mediated osteoblast differentiation.Journal of orthopaedic surgery and research · 2025Article
- Extended view on the mechanobiology of fracture healing: interplay between mechanics and inflammation.Frontiers in bioengineering and biotechnology · 2025Review
- A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils.Frontiers in bioengineering and biotechnology · 2025Article
- Use of bone callus as a source of bone graft for concurrent tibial malunion repair and contralateral pantarsal arthrodesis in a domestic shorthair cat-a case report.Frontiers in veterinary science · 2025Article
- Review
- Activation of Wnt signaling in human fracture callus and nonunion tissues.Bone reports · 2024Article
- Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing.Bioactive materials · 2024Article
- The local and systemic effects of immune function on fracture healing.OTA international : the open access journal of orthopaedic trauma · 2024Review
- A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing.Cureus · 2024Review
- Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants.Biomaterials research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Fracture-healing is a complex multi-stage process that usually progresses flawlessly, resulting in restoration of bone architecture and function. Regrettably, however, a considerable number of fractures fail to heal, resulting in delayed unions or non-unions. This may significantly impact several aspects of a patient's life. Not surprisingly, in the past few years, a substantial amount of research and number of clinical studies have been designed, aiming at shedding light into the cellular and molecular mechanisms that regulate fracture-healing. Herein, we present the current knowledge on the pathobiology of the fracture-healing process. In addition, the role of skeletal cells and the impact of marrow adipose tissue on bone repair is discussed. Unveiling the pathogenetic mechanisms that govern the fracture-healing process may lead to the development of novel, smarter, and more effective therapeutic strategies for the treatment of fractures, especially of those with large bone defects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.