ArticleFoods (Basel, Switzerland)2021
Preparation of Liposomes from Soy Lecithin Using Liquefied Dimethyl Ether.
Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Co-Encapsulation of Doxorubicin HCl and Paclitaxel in Nanovesicles for Enhanced Breast Cancer Therapy.AAPS PharmSciTech · 2025Article
- Innovative Approaches to Enhancing the Biomedical Properties of Liposomes.Pharmaceutics · 2024Review
- Effect of microwave (MW)-subcritical extraction on oil recovery, oxidative stability, and lipid types fromFood chemistry: X · 2024Article
- A Comprehensive Review on Novel Lipid-Based Nano Drug Delivery.Advanced pharmaceutical bulletin · 2024Review
- Extraction and Separation of Natural Products from Microalgae and Other Natural Sources Using Liquefied Dimethyl Ether, a Green Solvent: A Review.Foods (Basel, Switzerland) · 2024Review
- Lipid-Based Nanotechnology: Liposome.Pharmaceutics · 2023Review
- Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We investigated a method to prepare liposomes; soy lecithin was dissolved in liquefied dimethyl ether (DME) at 0.56 MPa, which was then injected into warm water. Liposomes can be successfully prepared at warm water temperatures above 45 °C. The transmission electron microscopy (TEM) images of the obtained liposomes, size distribution, ζ-potential measurements by dynamic light scattering and the amount of residual medium were compared by gas chromatography using the conventional medium, diethyl ether. The size of the obtained liposomes was approximately 60-300 nm and the ζ-potential was approximately -57 mV, which was almost the same as that of the conventional medium. Additionally, for the conventional media, a large amount remained in the liposome dispersion even after removal by depressurization and dialysis membrane treatment; however, liquefied DME, owing to its considerably low boiling point, was completely removed by depressurization. Liquefied DME is a very attractive medium for the preparation of liposomes because it does not have the toxicity and residue problems of conventional solvents or the hazards of ethanol addition and high pressure of supercritical carbon dioxide; it is also environmentally friendly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.