ArticleDiagnostics (Basel, Switzerland)2021
Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05950230 (A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients), which is not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Levels of IL-1β, MMP-8, and MMP-9 in the Saliva of Subjects With Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical laboratory analysis · 2025Pooled it
- Pooled it
- Assessment of salivary matrix metalloproteinase (MMP8) and activated salivary matrix metalloproteinase (aMMP8) in periodontitis patients: a systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- The Potential of Gingival Crevicular Fluid as a Tool for Molecular Diagnosis: A Systematic Review.BioMed research international · 2024Pooled it
- Trial
- Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation.The Journal of clinical investigation · 2021Trial
- The immune-microbe-metal triad: a vicious cycle driving biomaterial corrosion in the oral inflammatory microenvironment.Bioactive materials · 2027Review
- Diagnostic and prognostic value of serum Hcy and aMMP-8 levels in patients with acute pancreatitis : Value of serum Hcy and aMMP-8 in AP.Langenbeck's archives of surgery · 2026Article
- Active Matrixmetalloproteinase-8 in Periodontal Diagnosis: A Scoping Review.Diagnostics (Basel, Switzerland) · 2025Review
- Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease.Microorganisms · 2025Review
- The Role of Oral Biomarkers in the Assessment of Noncommunicable Diseases.Diagnostics (Basel, Switzerland) · 2024Review
- The Association of Matrix Metalloproteinase-1, -2, -3, -7, and -13 Gene Polymorphisms With Peri-Implantitis in an Iranian Population: A Case-Control Study.Clinical and experimental dental research · 2024Article
- Evaluating salivary MMP-8 as a biomarker for periodontal diseases: A systematic review and meta-analysis.Heliyon · 2024Article
- The Effectiveness of Individualized Oral Hygiene Education in Preventing Dental Diseases: A Clinical Study.Journal of clinical medicine · 2024Article
- aMMP-8 POCT vs. Other Potential Biomarkers in Chair-Side Diagnostics and Treatment Monitoring of Severe Periodontitis.International journal of molecular sciences · 2024Article
- Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.International journal of molecular sciences · 2024Review
- Minocycline hydrochloride plus metronidazole versus metronidazole alone for peri-implantitis: a comparative study.American journal of translational research · 2024Article
- Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation.Immunological reviews · 2023Review
- Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of Chronic Periodontitis.Reports of biochemistry & molecular biology · 2023Article
- Assessing salivary matrix metalloproteinase-8 in prostate cancer patients undergoing androgen deprivation therapy.Clinical and experimental dental research · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Periodontitis is a host-mediated bacterial disease that affects the tooth attachment apparatus. Metalloproteinase-8 (MMP-8), a validated biomarker, could aid in clinical diagnosis. This study aimed to evaluate the diagnostic performance of active (a) MMP-8 immunotest versus total (t) MMP-8 ELISA for quantitative real-time diagnosis and assessment of periodontitis severity at the site level. Gingival crevicular fluid (GCF) was sampled from 30 healthy, 42 mild, and 59 severe periodontitis sites from thirty-one volunteers. MMP-8 concentrations were determined by time-resolved immunofluorometric assay (IFMA) and enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using the STATA package. Both active and total MMP-8-based methods discriminated among sites according to periodontal diagnosis and severity, with a positive correlation between the two tests (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.