ArticleDiagnostics (Basel, Switzerland)2021
Metabolic Changes in Maternal and Cord Blood in One Case of Pregnancy-Associated Breast Cancer Seen by Fluorescence Lifetime Imaging Microscopy.
Li Zhou, Yawei Kong, Junxin Wu, Xingzhi Li, Yiyan Fei, Jiong Ma, Yulan Wang, Lan Mi
Abstract read
In one paragraphArticle in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Li ZhouShanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.
Yawei KongShanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.
Junxin WuShanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.
Xingzhi LiSchool of Materials Science and Engineering, Hubei University of Automotive Technology, 167 Checheng West Road, Shiyan 442002, China.
Yiyan FeiShanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.ORCID 0000-0002-2413-130X Jiong MaShanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.ORCID 0000-0003-3632-4624 Yulan WangDepartment of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Str., Wuhan 430014, China.
Lan MiShanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.ORCID 0000-0002-2320-2225 Funding
Fudan University-CIOMP Joint Fund FC2018-001Pioneering Project of Academy for Engineering and Technology, Fudan University gyy2018-001Pioneering Project of Academy for Engineering and Technology, Fudan University gyy2018-002Science and Technology Research Program of Shanghai 19DZ2282100Shanghai Engineering Technology Research Center of Hair Medicine 19DZ2250500Shanghai key discipline construction plan (2020-2022) GWV-10.1-XK01Shanghai Natural Science Foundation 20ZR1403700Shanghai Natural Science Foundation 20ZR1405100
6 · The paper itselfAbstract
Pregnancy-associated breast cancer (PABC) is a rare disease, which is frequently diagnosed at an advanced stage due to limitations in current diagnostic methods. In this study, fluorescence lifetime imaging microscopy (FLIM) was used to study the metabolic changes by measuring maternal blood and umbilical cord blood via the autofluorescence of coenzymes, reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H), and flavin adenine dinucleotide (FAD). The NAD(P)H data showed that a PABC case had significant differences compared with normal cases, which may indicate increased glycolysis. The FAD data showed that both maternal and cord blood of PABC had shorter mean lifetimes and higher bound-FAD ratios. The significant differences suggested that FLIM testing of blood samples may be a potential method to assist in PABC non-radiative screening.
Indexed as
bloodFADfluorescence lifetime imaging microscopyNAD(P)Hpregnancy-associated breast cancer
Identifiers
PMID34441428
PMCPMC8392038
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