Evidence map›Paper›PMID 34441409›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Detection of

Selena Y Lin, Ting-Tsung Chang, Jamin D Steffen, Sitong Chen, Surbhi Jain, Wei Song, Yih-Jyh Lin, Ying-Hsiu Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Geographic and Viral Etiology Patterns ofInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Selena Y LinJBS Science, Inc., Doylestown, PA 18902, USA.
Ting-Tsung ChangDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-5073-2678
Jamin D SteffenJBS Science, Inc., Doylestown, PA 18902, USA.
Sitong ChenJBS Science, Inc., Doylestown, PA 18902, USA.
Surbhi JainJBS Science, Inc., Doylestown, PA 18902, USA.
Wei SongJBS Science, Inc., Doylestown, PA 18902, USA.
Yih-Jyh LinDepartment of Surgery, National Cheng Kung University Medical College and Hospital, Tainan 701, Taiwan.
Ying-Hsiu SuThe Baruch S. Blumberg Research Institute, Doylestown, PA 18902, USA.
JBS Science (United States) · USBaruch S. Blumberg Institute · USNational Cheng Kung University · TWNational Cheng Kung University Hospital · TW

Funding

Development of a Urine Test for the Early Detection of Liver CancerR44CA165312 · NCI · JBS SCIENCE, INC. · PI LIN, SELENA · 2013 to 2020
$4.9M
Development of cell-free DNA assays for HCC screening and liquid biopsyR01CA202769 · NCI · BARUCH S. BLUMBERG INSTITUTE · PI SU, YING-HSIU · 2016 to 2020
$2.1M
NCI NIH HHS R01 CA202769NCI NIH HHS R44 CA165312
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. The beta-catenin gene,

Indexed as

beta-catenincell-free DNAhepatocellular carcinomamutationrecurrenceurine

Identifiers

PMID34441409
PMCPMC8393790
OpenAlexW3195627801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.