Evidence map›Paper›PMID 34441371›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Alzheimer's Disease and Frontotemporal Dementia: A Robust Classification Method of EEG Signals and a Comparison of Validation Methods.

Andreas Miltiadous, Katerina D Tzimourta, Nikolaos Giannakeas, Markos G Tsipouras, Theodora Afrantou, Panagiotis Ioannidis, Alexandros T Tzallas

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andreas MiltiadousDepartment of Informatics and Telecommunications, School of Informatics and Telecommunications, University of Ioannina, Kostakioi, 47 100 Arta, Greece.ORCID 0000-0003-0675-9088
Katerina D TzimourtaDepartment of Electrical and Computer Engineering, Faculty of Engineering, University of Western Macedonia, 50 100 Kozani, Greece.ORCID 0000-0001-9640-7005
Nikolaos GiannakeasDepartment of Informatics and Telecommunications, School of Informatics and Telecommunications, University of Ioannina, Kostakioi, 47 100 Arta, Greece.ORCID 0000-0002-0615-783X
Markos G TsipourasDepartment of Electrical and Computer Engineering, Faculty of Engineering, University of Western Macedonia, 50 100 Kozani, Greece.
Theodora Afrantou2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, GR54636 Thessaloniki, Greece.ORCID 0000-0003-2009-4166
Panagiotis Ioannidis2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, GR54636 Thessaloniki, Greece.ORCID 0000-0003-0254-6624
Alexandros T TzallasDepartment of Informatics and Telecommunications, School of Informatics and Telecommunications, University of Ioannina, Kostakioi, 47 100 Arta, Greece.ORCID 0000-0001-9043-1290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia is the clinical syndrome characterized by progressive loss of cognitive and emotional abilities to a degree severe enough to interfere with daily functioning. Alzheimer's disease (AD) is the most common neurogenerative disorder, making up 50-70% of total dementia cases. Another dementia type is frontotemporal dementia (FTD), which is associated with circumscribed degeneration of the prefrontal and anterior temporal cortex and mainly affects personality and social skills. With the rapid advancement in electroencephalogram (EEG) sensors, the EEG has become a suitable, accurate, and highly sensitive biomarker for the identification of neuronal and cognitive dynamics in most cases of dementia, such as AD and FTD, through EEG signal analysis and processing techniques. In this study, six supervised machine-learning techniques were compared on categorizing processed EEG signals of AD and FTD cases, to provide an insight for future methods on early dementia diagnosis. K-fold cross validation and leave-one-patient-out cross validation were also compared as validation methods to evaluate their performance for this classification problem. The proposed methodology accuracy scores were 78.5% for AD detection with decision trees and 86.3% for FTD detection with random forests.

Indexed as

Alzheimer’s diseaseclassificationdementiaEEGelectroencephalogramfrontotemporal dementiak-foldleave-one-patient-out

Identifiers

PMID34441371
PMCPMC8391578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.