Evidence map›Paper›PMID 34441341›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Cholesterol Efflux Capacity Associates with the Ankle-Brachial Index but Not All-Cause Mortality in Patients with Peripheral Artery Disease.

Robert K Clemens, Monika Hunjadi, Andreas Ritsch, Lucia Rohrer, Thomas O Meier, Beatrice Amann-Vesti, Arnold von Eckardstein, Wijtske Annema

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In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert K ClemensVascular Center, Cantonal Hospital Baden, University of Zurich, Im Ergel 1, CH-5404 Baden, Switzerland.
Monika HunjadiDepartment of Internal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-4285-2925
Andreas RitschDepartment of Internal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-0417-5161
Lucia RohrerInstitute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.
Thomas O MeierClinic for Angiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.
Beatrice Amann-VestiAngiology, Clinic in the Park, Seestrasse 220, CH-8027 Zurich, Switzerland.
Arnold von EckardsteinInstitute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.ORCID 0000-0002-1666-2266
Wijtske AnnemaInstitute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

Funding

Austrian Science Fund FWF P 27116
6 · The paper itself

Abstract

backgroundCholesterol efflux is an important mechanism by which high-density lipoproteins (HDLs) protect against cardiovascular disease. As peripheral artery disease (PAD) is associated with high mortality rates, mainly due to cardiovascular causes, we investigated whether cholesterol efflux capacity (CEC) of apolipoprotein B (apoB)-depleted plasma, a widely used surrogate of HDL function, may serve as a predictive marker for mortality in this patient population.

methodsIn this prospective single-center study (median follow-up time: 9.3 years), apoB-containing lipoproteins were precipitated from plasma of 95 patients with PAD and incubated with J744-macrophages, which were loaded with radiolabeled cholesterol. CEC was defined as the fractional radiolabel released during 4 h of incubation.

resultsBaseline CEC was lower in PAD patients that currently smoked (

conclusionTaken together, CEC is associated with ABI but does not predict all-cause mortality in patients with PAD.

Indexed as

cholesterol efflux capacityhigh-density lipoproteinperipheral artery diseaserisk prediction

Identifiers

PMID34441341
PMCPMC8394478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.