ReviewDiagnostics (Basel, Switzerland)2021
Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases.
Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An Umbrella Review of E-Cigarettes' Impact on Oral Microbiota and Biofilm Buildup.Pathogens (Basel, Switzerland) · 2025Pooled it
- Salivary Microbiome Differences in Stunted and Healthy Children: A Metagenomic Analysis.European journal of dentistry · 2026Article
- Lifestyle Characteristics and Dietary Habits in Romanian Patients with Periodontitis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Oral Microbiota, the Oral-Brain Axis, and Neurodegeneration: Mechanisms and Dietary Modulation.Antioxidants (Basel, Switzerland) · 2026Review
- Oral Microbial Extracellular Vesicles as Novel Mediators of Alzheimer's Pathogenesis: A Critical Review of the Periodontal-Brain Axis.Neurotoxicity research · 2026Review
- A cross-sectional study of supragingival microbiome depending on age in Korean population.Scientific reports · 2026Article
- The Oral-Gut-Immune-Nutrition Axis in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Polyphenols Limit Cerebral Endothelial Cell Dysfunction Under Inflammatory Conditions Related to Oral and Gut Microbiota.Nutrients · 2026Article
- Oral Microbiota and Type 2 Diabetes: Interactions, Potential Mechanisms, and Preventive Strategies.Microorganisms · 2026Review
- Early pregnancy is characterized by a significant decrease in the diversity of the oral microbiome and strong associations with lifestyle and conception method.Journal of oral microbiology · 2026Article
- The oral microbiome as a regulatory hub for systemic health: a systematic review of mechanistic links and clinical implications.Journal of oral microbiology · 2026Review
- Alteration in tongue coating microbiota across different stages of hepatitis B virus-related chronic liver disease.Journal of oral microbiology · 2026Article
- Conclusions about a link between SAPHO syndrome, IgA nephropathy and dental amalgams can only be drawn after extensive analysis.BMC nephrology · 2025Article
- Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data.BMC oral health · 2025Article
- Awareness, Perception, and Knowledge about Oral Microbiota among College of Dentistry Students in Gulf Medical University/United Arab Emirates.Journal of pharmacy & bioallied sciences · 2025Article
- Desquamative Gingivitis and the Oral Microbiome: Insights into Immune-Microbial Interactions in Mucosal Inflammation.Dentistry journal · 2025Review
- Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- The Infant Oral Microbiome: Developmental Dynamics, Modulating Factors, and Implications for Oral and Systemic Health.International journal of molecular sciences · 2025Review
- Effects of Antiseptic Formulations on Oral Microbiota and Related Systemic Diseases: A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- The Oral-Gut Microbiota Axis Across the Lifespan: New Insights on a Forgotten Interaction.Nutrients · 2025Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral cavity is host to a complex and diverse microbiota community which plays an important role in health and disease. Major oral infections, i.e., caries and periodontal diseases, are both responsible for and induced by oral microbiota dysbiosis. This dysbiosis is known to have an impact on other chronic systemic diseases, whether triggering or aggravating them, making the oral microbiota a novel target in diagnosing, following, and treating systemic diseases. In this review, we summarize the major roles that oral microbiota can play in systemic disease development and aggravation and also how novel tools can help investigate this complex ecosystem. Finally, we describe new therapeutic approaches based on oral bacterial recolonization or host modulation therapies. Collaboration in diagnosis and treatment between oral specialists and general health specialists is of key importance in bridging oral and systemic health and disease and improving patients' wellbeing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.