ArticleDiagnostics (Basel, Switzerland)2021
A Novel Approach to Classification and Reporting of Lymph Node Fine-Needle Cytology: Application of the Proposed Sydney System.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Sydney system for lymph node FNA biopsy cytopathology: A detailed analysis of recent publications and meta-analysis and a proposal for the components of an ideal prospective study of a cytopathology reporting system.Cancer cytopathology · 2024Pooled it
- Application of Sydney System for Lymph Node Cytology at a Tertiary Care Centre in Central India.Diagnostic cytopathology · 2026Article
- Retrospective single-center cytohistologic correlation study of fine-needle aspiration cytology for excised superficial enlarged lymph node lesions in different disease entities.Discover oncology · 2026Article
- The Atypical and Suspicious for Malignancy Categories of the WHO Reporting System for Lymph Node, Spleen, and Thymus Cytopathology: Review of their Diagnostic Utility, Limitations, and Clinical Impact.Diagnostic cytopathology · 2026Review
- Bridging Cytology and Histology: Concordance Analysis of Lymph Node Lesions within the Sydney Framework.Iranian journal of pathology · 2026Article
- Risk Assessment of Diagnostic Categories in the Proposed Sydney System for Reporting Lymph Node Cytopathology: A Retrospective Cytomorphological Study.Iranian journal of pathology · 2026Article
- Not Enough Cells: How Insufficient Cytological Specimens Are Mirrored by Reporting Systems - Journey from the Bethesda to the WHO Reporting Systems.Acta cytologica · 2026Review
- Ultrasound-guided fine-needle cytology for cervical lymph nodes: a tertiary centre's experience with the Sydney system.Annals of medicine · 2025Article
- Sydney Reporting System for Lymph Node Fine-Needle Aspiration and Malignancy Risk Stratification: Is It of Clinical Value?Diagnostics (Basel, Switzerland) · 2024Article
- Diagnostic Accuracy of Lymph Nodes Fine Needle Aspiration Biopsy Based on The Sydney System for Reporting Lymph Node Cytology.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy.Diagnostics (Basel, Switzerland) · 2023Article
- Cyto-Histopathological Correlations in Pathology Diagnostics.Diagnostics (Basel, Switzerland) · 2022Article
- [New aspects in fine needle biopsies of the lymph nodes].Der Pathologe · 2022Review
- Diagnostic Utility of the Sydney System in Lymph Node Cytopathology: A Retrospective Analysis.Sage open pathologyArticle
- Application of the Sydney System for Classification and Reporting Lymph Node Cytopathology to Assess the Risk of Malignancy and its Diagnostic Accuracy.Journal of cytologyArticle
- Evaluation of Fine-Needle Aspiration of Lymph Nodes and Assessment of Risk of Malignancy Based on the Sydney System of Reporting Lymph Node Cytology.Journal of cytologyArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fine-needle cytology (FNC) is a useful diagnostic tool in the first line evaluation of lymphadenopathy of unknown aetiology. Nevertheless, considering the large number of conditions presenting as lymphadenopathy, lymph node cytology represents a challenging scenario. Recently, an expert panel published the proposal of the Sydney system for performing classification and reporting of lymph node cytopathology; the aim of the present study was to evaluate the applicability of this system. Thus, 300 lymph node FNCs performed over 1 year were reviewed and categorized according to the Sydney system classification. Overall, n = 20 cases (6.7%) were categorized as L1-inadequate/non-diagnostic; n = 104 (34.7%) as benign (L2); n = 25 (8.3%) as atypical (L3); n = 13 (4.3%) as suspicious (L4), and n = 138 (46%) as malignant (L5). FNC diagnoses were correlated with histopathologic and clinical follow-up to assess the diagnostic accuracy and the risk of malignancy (ROM) for each diagnostic category. Statistical analysis showed the following results: sensitivity 98.47%, specificity 95.33%, positive predictive value 96.27%, negative predictive value 98.08%, and accuracy 97.06%. The ROM was 50% for the category L1, 1.92% for L2, 58.3% for L3, and 100% for L4 and L5. In conclusion, FNC coupled with ancillary techniques ensures satisfactory diagnostic accuracy and the implementation of the Sydney system may improve the practice of cytopathologists.
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