Evidence map›Paper›PMID 34441171›Full record

ArticleEntropy (Basel, Switzerland)2021

A Transcriptome Community-and-Module Approach of the Human Mesoconnectome.

Omar Paredes, Jhonatan B López, César Covantes-Osuna, Vladimir Ocegueda-Hernández, Rebeca Romo-Vázquez, J Alejandro Morales

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omar ParedesComputer Sciences Department, Exact Sciences and Engineering University Centre, Universidad de Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0002-5382-6127
Jhonatan B LópezComputer Sciences Department, Exact Sciences and Engineering University Centre, Universidad de Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0002-3733-9863
César Covantes-OsunaComputer Sciences Department, Exact Sciences and Engineering University Centre, Universidad de Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0002-8671-6549
Vladimir Ocegueda-HernándezComputer Sciences Department, Exact Sciences and Engineering University Centre, Universidad de Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0002-1942-452X
Rebeca Romo-VázquezComputer Sciences Department, Exact Sciences and Engineering University Centre, Universidad de Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0001-6459-8070
J Alejandro MoralesComputer Sciences Department, Exact Sciences and Engineering University Centre, Universidad de Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0001-8088-9724

Funding

Consejo Nacional de Ciencia y Tecnología, México 427103Consejo Nacional de Ciencia y Tecnología, México 480527Consejo Nacional de Ciencia y Tecnología, México 713526Consejo Nacional de Ciencia y Tecnología, México 745514
6 · The paper itself

Abstract

Graph analysis allows exploring transcriptome compartments such as communities and modules for brain mesostructures. In this work, we proposed a bottom-up model of a gene regulatory network to brain-wise connectome workflow. We estimated the gene communities across all brain regions from the Allen Brain Atlas transcriptome database. We selected the communities method to yield the highest number of functional mesostructures in the network hierarchy organization, which allowed us to identify specific brain cell functions (e.g., neuroplasticity, axonogenesis and dendritogenesis communities). With these communities, we built brain-wise region modules that represent the connectome. Our findings match with previously described anatomical and functional brain circuits, such the default mode network and the default visual network, supporting the notion that the brain dynamics that carry out low- and higher-order functions originate from the modular composition of a GRN complex network.

Indexed as

Allen Brain Atlasbottom-up modelingbrain transcriptomegene regulatory networkgraph communitiesmesoconnectome

Identifiers

PMID34441171
PMCPMC8393183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.