Evidence map›Paper›PMID 34441045›Full record

ReviewMedicina (Kaunas, Lithuania)2021

Mechanisms and Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds-A Review.

Antony V Samrot, Amira Abubakar Mohamed, Etel Faradjeva, Lee Si Jie, Chin Hooi Sze, Akasha Arif, Tan Chuan Sean, Emmanuel Norbert Michael, Chua Yeok Mun, Ng Xiao Qi and 2 more

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Comparative fermentation performance of biofilm and planktonic Saccharomyces cerevisiae under standard and high-carbon media.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Antibiofilm Activity ofInternational journal of microbiology · 2026
    Article
  8. Article
  9. Antimicrobial resistance and biofilm-forming ability inVeterinary and animal science · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Lipophilic Extracts ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Enhancing the destruction ofFrontiers in cellular and infection microbiology · 2025
    Article
  18. Review
  19. Article
  20. Biofilm · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antony V SamrotSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.ORCID 0000-0001-9536-0567
Amira Abubakar MohamedSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Etel FaradjevaSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.ORCID 0000-0002-5199-2527
Lee Si JieSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Chin Hooi SzeSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Akasha ArifSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Tan Chuan SeanSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.ORCID 0000-0002-3517-0494
Emmanuel Norbert MichaelSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Chua Yeok MunSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Ng Xiao QiSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Pooi Ling MokDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia.ORCID 0000-0001-9688-0716
Suresh S KumarDepartment of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia.ORCID 0000-0002-0505-7554

Funding

Universiti Putra Malaysia High Impact Grant 'Geran Berimpak' 9674600
6 · The paper itself

Abstract

Biofilms comprising aggregates of microorganisms or multicellular communities have been a major issue as they cause resistance against antimicrobial agents and biofouling. To date, numerous biofilm-forming microorganisms have been identified, which have been shown to result in major effects including biofouling and biofilm-related infections. Quorum sensing (which describes the cell communication within biofilms) plays a vital role in the regulation of biofilm formation and its virulence. As such, elucidating the various mechanisms responsible for biofilm resistance (including quorum sensing) will assist in developing strategies to inhibit and control the formation of biofilms in nature. Employing biological control measures (such as the use of bioactive compounds) in targeting biofilms is of great interest since they naturally possess antimicrobial activity among other favorable attributes and can also possibly act as potent antibiofilm agents. As an effort to re-establish the current notion and understanding of biofilms, the present review discuss the stages involved in biofilm formation, the factors contributing to its development, the effects of biofilms in various industries, and the use of various bioactive compounds and their strategies in biofilm inhibition.

Indexed as

BiofilmsQuorum SensingAnti-Bacterial AgentsAnti-Bacterial Agentsantibiofilm agentsbioactive compoundsbiofilm-related Infectionsbiofilmsbiofoulingbiological controlquorum sensing

Identifiers

PMID34441045
PMCPMC8401077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.