Evidence map›Paper›PMID 34440927›Full record

ArticleCells2021

Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage.

Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S Contreras, Robert Hardt, Thea van den Bosch, Alejandra R Alvarez, Boris Rebolledo-Jaramillo, Andres D Klein, Dominic Winter and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Elisa BalboaDepartamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Tamara MarínDepartamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Juan Esteban OyarzúnDepartamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Pablo S ContrerasCell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8018, USA.ORCID 0000-0002-1468-412X
Robert HardtInstitute for Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, 53115 Bonn, Germany.ORCID 0000-0003-2939-7657
Thea van den BoschInstitute for Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, 53115 Bonn, Germany.
Alejandra R AlvarezLaboratory of Cell Signaling, Department of Cellular and Molecular Biology, Biological Sciences Faculty, CARE UC, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
Boris Rebolledo-JaramilloCentro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7710162, Chile.ORCID 0000-0001-8059-3202
Andres D KleinCentro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7710162, Chile.ORCID 0000-0002-9951-2174
Dominic WinterInstitute for Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, 53115 Bonn, Germany.ORCID 0000-0001-6788-6641
Silvana ZanlungoDepartamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.ORCID 0000-0001-8383-9829
Pontificia Universidad Católica de Chile · CLUniversity of Bonn · DEUniversidad del Desarrollo · CLNational Institutes of Health · US

Funding

Comisión Nacional de Investigación Científica y Tecnológica-Chile AFB170005FONDEQUIP EQM150093Fondo Nacional de Desarrollo Científico y Tecnológico 1161065Fondo Nacional de Desarrollo Científico y Tecnológico 1180337Fondo Nacional de Desarrollo Científico y Tecnológico 1190334Fondo Nacional de Desarrollo Científico y Tecnológico 1201668
6 · The paper itself

Abstract

Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the

Indexed as

AnimalsBlotting, WesternCells, CulturedHepatocytesLiverLiver DiseasesMaleMiceNiemann-Pick Disease, Type CProteomeProteomeliver damagelysosomal storage disordermass spectrometryNiemann Pick type C diseaseproteomic analysis

Identifiers

PMID34440927
PMCPMC8392304
OpenAlexW3194749402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.