Evidence map›Paper›PMID 34440916›Full record

ArticleCells2021

Identifying the Effects of Reactive Oxygen Species on Mitochondrial Dynamics and Cytoskeleton Stability in

Evan Downs, Amber D Bottrell, Kari Naylor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Transcriptome-Based WGCNA Reveals Hub Genes Involved in Copper Resistance ofInternational journal of molecular sciences · 2026
    Article
  2. Frontiers in tuberculosis · 2025
    Review
  3. Review
  4. The aerotaxis ofFrontiers in cell and developmental biology · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Evan DownsDepartment of Biology, University of Central Arkansas, Conway, AR 72035, USA.
Amber D BottrellDepartment of Biology, University of Central Arkansas, Conway, AR 72035, USA.
Kari NaylorDepartment of Biology, University of Central Arkansas, Conway, AR 72035, USA.ORCID 0000-0002-3222-1540
University of Central Arkansas · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

Defects in mitochondrial dynamics, fission, fusion, and motility have been implicated in the pathogenesis of multiple neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and Charcot-Marie-Tooth disease. Another key feature of neurodegeneration is the increase in reactive oxygen species (ROS). Previous work has shown that the cytoskeleton, in particular the microtubules, and ROS generated by rotenone significantly regulate mitochondrial dynamics in

Indexed as

Mitochondrial DynamicsAlzheimer DiseaseAntimycin ABenzene DerivativesCharcot-Marie-Tooth DiseaseCytoskeletonDictyosteliumHumansHuntington DiseaseHydroxylamineMicrotubulesMitochondriaModels, BiologicalParkinson DiseaseReactive Oxygen SpeciesAntimycin ABenzene Derivativescumene hydroperoxideHydroxylamineReactive Oxygen Speciesfissionfusionmicrotubulesmitochondrial dynamicsmotilityROS

Identifiers

PMID34440916
PMCPMC8392674
OpenAlexW3193658261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.