Evidence map›Paper›PMID 34440913›Full record

ArticleCells2021

Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells.

Andreas Schmid, Ann-Kathrin Vlacil, Jutta Schuett, Thomas Karrasch, Bernhard Schieffer, Andreas Schäffler, Karsten Grote

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Adipokines in atherosclerosis: unraveling complex roles.Frontiers in cardiovascular medicine · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andreas SchmidDepartment of Internal Medicine III, University of Giessen, 35390 Giessen, Germany.
Ann-Kathrin VlacilDepartment of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
Jutta SchuettDepartment of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
Thomas KarraschDepartment of Internal Medicine III, University of Giessen, 35390 Giessen, Germany.
Bernhard SchiefferDepartment of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.
Andreas SchäfflerDepartment of Internal Medicine III, University of Giessen, 35390 Giessen, Germany.
Karsten GroteDepartment of Cardiology and Angiology, Philipps-University Marburg, 35037 Marburg, Germany.ORCID 0000-0001-7914-3159
Philipps University of Marburg · DEJustus-Liebig-Universität Gießen · DE

Funding

Deutsche Forschungsgemeinschaft DFG SCHM 3261/3-1
6 · The paper itself

Abstract

The C1q/TNF-related protein 3 (CTRP3) represents a pleiotropic adipokine reciprocally associated with obesity and type 2 diabetes mellitus and exhibits anti-inflammatory properties in relation to lipopolysaccharides (LPS)-mediated effects in adipocytes, as well as monocytes/macrophages. Here, we focused on the influence of CTRP3 on LPS-mediated effects in endothelial cells in order to expand the understanding of a possible anti-inflammatory function of CTRP3 in a setting of endotoxemia. An organ- and tissue-specific expression analysis by real-time PCR revealed a considerable Ctrp3 expression in various adipose tissue compartments; however, higher levels were detected in the aorta and in abundantly perfused tissues (bone marrow and the thyroid gland). We observed a robust Ctrp3 expression in primary endothelial cells and a transient upregulation in murine endothelial (MyEND) cells by LPS (50 ng/mL). In MyEND cells, CTRP3 inhibited the LPS-induced expression of interleukin

Indexed as

Gene Expression ProfilingAdipokinesAdipose TissueAnimalsCell AdhesionCell Adhesion MoleculesCell LineCytokinesEndothelial CellsGene Expression RegulationHumansInflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLAdipokinesCell Adhesion MoleculesCORS26 protein, mouseCytokinesLipopolysaccharidesToll-Like Receptor 4adipocytesadipose tissueCTRP3endothelial cellsendotoxininfectioninflammation

Identifiers

PMID34440913
PMCPMC8391708
OpenAlexW3195787881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.