Evidence map›Paper›PMID 34440912›Full record

ArticleCells2021

Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8

Yao Chen, Jian Shen, Moujtaba Y Kasmani, Paytsar Topchyan, Weiguo Cui

Abstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Dapl1Science advances · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Leukocyte dynamics inFrontiers in immunology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Aberrant CD8Frontiers in immunology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yao ChenVersiti Blood Research Institute, Milwaukee, WI 53213, USA.
Jian ShenVersiti Blood Research Institute, Milwaukee, WI 53213, USA.ORCID 0000-0001-8398-2318
Moujtaba Y KasmaniVersiti Blood Research Institute, Milwaukee, WI 53213, USA.
Paytsar TopchyanVersiti Blood Research Institute, Milwaukee, WI 53213, USA.ORCID 0000-0002-3902-7652
Weiguo CuiVersiti Blood Research Institute, Milwaukee, WI 53213, USA.ORCID 0000-0003-1562-9218

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Reprogramming tumor-reactive CD8 T cells by targeting the IL-21-BATF pathway to treat melanomaF30CA246920 · NCI · VERSITI WISCONSIN, INC. · PI TOPCHYAN, PAYTSAR · 2020 to 2023
$200k
Mechanistic study of TCR signaling strength in CD8 T cell differentiation during pathogenesis of T1DMF30DK127526 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI KASMANI, MOUJTABA Y · 2020 to 2023
$198k
NCI NIH HHS F30 CA246920NIDDK NIH HHS F30 DK127526NIGMS NIH HHS T32 GM080202NIH HHS AI125741NIH HHS AI148403
6 · The paper itself

Abstract

During acute infections, CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCell LineCells, CulturedFemaleGene Expression ProfilingImmunologic MemoryIntestine, SmallLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLRNA-SeqSingle-Cell AnalysisSpleenCD8 tissue-resident memory T cellGP33heterogeneityLCMV infectionsingle-cell RNA-sequencingtranscriptional regulationtranscription factors

Identifiers

PMID34440912
PMCPMC8392357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.