Evidence map›Paper›PMID 34440862›Full record

ArticleCells2021

Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1.

Harrison T Muturi, Saja S Khuder, Hilda E Ghadieh, Emily L Esakov, Hyelim Noh, Heejoon Kang, Marcia F McInerney, Jason K Kim, Abraham D Lee, Sonia M Najjar

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.Metabolism: clinical and experimental · 2023
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Harrison T MuturiDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Saja S KhuderCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.
Hilda E GhadiehDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Emily L EsakovCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.ORCID 0000-0002-5049-2096
Hyelim NohProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-9284-0557
Heejoon KangProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Marcia F McInerneyCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.ORCID 0000-0001-9348-2480
Jason K KimProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Abraham D LeeDepartment of Rehabilitation Sciences, Judith Herb College of Education, Human Science and Human Service, The University of Toledo, Toledo, OH 43606, USA.
Sonia M NajjarDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
University of Toledo · USOhio University · USUniversity of Massachusetts Chan Medical School · US

Funding

SUBSTRATES AND INSULIN RECEPTOR ENDOCYTOSISR01DK054254 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2000 to 2021
$5.8M
Novel pathways in the pathogenesis and pathophysiology of NAFLD in HispanicsR01MD012579 · NIMHD · OHIO UNIVERSITY ATHENS · PI FRIEDMAN, THEODORE C, NAJJAR, SONIA M. · 2019 to 2023
$3.2M
Linking fat metabolism to hepatic fibrosisR01DK124126 · NIDDK · OHIO UNIVERSITY ATHENS · PI NAJJAR, SONIA M., PURI, VISHWAJEET · 2020 to 2023
$2.1M
CEACAM1: A link between metabolic and cardiovascular diseasesR01HL112248 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2012 to 2016
$1.9M
Insulin resistance in the pathogenesis of NASHR01DK083850 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2009 to 2010
$749k
NHLBI NIH HHS R01 HL112248NIDDK NIH HHS R01 DK054254NIDDK NIH HHS R01 DK083850NIDDK NIH HHS R01 DK124126NIMHD NIH HHS R01 MD012579
6 · The paper itself

Abstract

CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the endothelium, we aimed at investigating the metabolic role of endothelial CEACAM1. To this end, we generated endothelial cell-specific

Indexed as

Insulin ResistanceAdipocytesAnimalsCarcinoembryonic AntigenEndothelial CellsEndothelium, VascularFatsGlucoseInflammationInsulinLiverMiceMice, KnockoutNF-kappa BNitric OxideSignal TransductionCarcinoembryonic AntigenCeacam1 protein, mouseFatsGlucoseInsulinNF-kappa BNitric Oxidecarcinoembryonic antigen-related cell adhesion molecule-1insulin clearanceinsulin resistanceinsulin transportnormo-insulinemia

Identifiers

PMID34440862
PMCPMC8394790
OpenAlexW3195738243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.