Evidence map›Paper›PMID 34440853›Full record

ArticleCells2021

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice.

María Vinaixa, Sandra Canelles, África González-Murillo, Vítor Ferreira, Diana Grajales, Santiago Guerra-Cantera, Ana Campillo-Calatayud, Manuel Ramírez-Orellana, Óscar Yanes, Laura M Frago and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

María VinaixaMetabolomics Platform, IISPV, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili, E-43002 Tarragona, Spain.
Sandra CanellesDepartment of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.
África González-MurilloUnidad de Terapias Avanzadas, Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.ORCID 0000-0001-7747-1204
Vítor FerreiraCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, E-28029 Madrid, Spain.ORCID 0000-0002-0107-9510
Diana GrajalesCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, E-28029 Madrid, Spain.ORCID 0000-0002-9332-6979
Santiago Guerra-CanteraDepartment of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.ORCID 0000-0002-3999-8416
Ana Campillo-CalatayudDepartment of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.
Manuel Ramírez-OrellanaUnidad de Terapias Avanzadas, Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.ORCID 0000-0003-0332-6973
Óscar YanesMetabolomics Platform, IISPV, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili, E-43002 Tarragona, Spain.ORCID 0000-0003-3695-7157
Laura M FragoDepartment of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.ORCID 0000-0002-5927-9240
Ángela M ValverdeCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, E-28029 Madrid, Spain.ORCID 0000-0003-1192-9045
Vicente BarriosDepartment of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009 Madrid, Spain.ORCID 0000-0002-5507-7545
Instituto de Salud Carlos III · ESHospital Infantil Universitario Niño Jesús · ES

Funding

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición CIBERDEMCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición CIBEROBNComunidad de Madrid S2017/BMD-3684Ministerio de Ciencia e Innovación FIS PI19/00166, BFU 2017-82565-C2-1-R, and RTI2018-094052-B-100
6 · The paper itself

Abstract

Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2

Indexed as

AnimalsBlood GlucoseChemokine CX3CL1CytokinesDiabetes Mellitus, ExperimentalEnergy MetabolismFatty Acids, UnsaturatedGlucose Transport Proteins, FacilitativeHypothalamusInsulin Receptor Substrate ProteinsInterleukin-1betaLeptinLipid MetabolismMiceMice, Inbred C57BLMice, KnockoutBlood GlucoseChemokine CX3CL1CytokinesFatty Acids, UnsaturatedGlucose Transport Proteins, FacilitativeInsulin Receptor Substrate ProteinsInterleukin-1betaIrs2 protein, mouseLeptindiabeteshypothalamusinflammationIRS2−/− micePUFA

Identifiers

PMID34440853
PMCPMC8391514
OpenAlexW3195759319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.