Stratified Mucin-Producing Intraepithelial Lesion (SMILE) of the Uterine Cervix: High-Risk HPV Genotype Predominance and p40 Immunophenotype.

Margareta Strojan Fležar, Neža Nedelko, Mario Poljak, Anja Oštrbenk Valenčak, Helena Gutnik

Open access · goldAbstract read

In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.1field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV-16 Positive Woman: A Rare Encounter.Infectious disorders drug targets · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Margareta Strojan FležarInstitute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.ORCID 0000-0001-6390-2253

Neža NedelkoInstitute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.

Mario PoljakInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška Cesta 4, 1000 Ljubljana, Slovenia.ORCID 0000-0002-3216-7564

Anja Oštrbenk ValenčakInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška Cesta 4, 1000 Ljubljana, Slovenia.

Helena GutnikInstitute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.

University of Ljubljana · SI

Funding

Horizon 2020 Framework Program for Research and Innovation of the European Commission 8447845Javna Agencija za Raziskovalno Dejavnost RS P3-0054Javna Agencija za Raziskovalno Dejavnost RS P3-0083

6 · The paper itself

Abstract

Stratified mucin-producing intraepithelial lesion (SMILE) is a rare high-grade cervical precancerous lesion designated a variant of adenocarcinoma in situ (AIS) in the WHO classification. We aimed to determine HPV genotypes, immunohistochemical phenotype and mucin presence in SMILE. Between 2010 and 2018, SMILE was diagnosed in 34 out of 6958 (0.5%) cervical biopsies, in 23 patients. Twenty-six tissue samples from twenty-one patients were available for further analysis, including 13 with SMILE alone, 12 with SIL and/or AIS and one with HSIL, AIS and endocervical adenocarcinoma. HPV genotyping was performed using the Seegene Anyplex II HPV 28 assay. Of the 26 samples, a single HPV genotype was identified in the majority of cases (

Indexed as

Adenocarcinoma in SituAdultBiomarkers, TumorCervix UteriCyclin-Dependent Kinase Inhibitor p16FemaleGenotypeHuman papillomavirus 16HumansImmunohistochemistryKi-67 AntigenMiddle AgedMucinsNeoplasm GradingRetrospective StudiesSquamous Intraepithelial LesionsBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Ki-67 AntigenMucinsTP63 protein, humanTranscription FactorsTumor Suppressor Proteinscervical precancerous lesionhigh-risk HPV typesHPV genotypingimmunohistochemistrystratified mucin-producing intraepithelial lesions

Identifiers

PMID34440808

DOI10.3390/cells10082039

PMCPMC8392541

OpenAlexW3191430280

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.