Evidence map›Paper›PMID 34440752›Full record

ArticleCells2021

Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models.

Jia Song, Yao Lu, Xiaoxia Cheng, Chuang Shi, Qiyong Lou, Xia Jin, Jiangyan He, Gang Zhai, Zhan Yin

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Experimentally Manipulating the Thyroid Hormone Axis in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  3. Combined Pituitary Hormone Deficiency inInternational journal of molecular sciences · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. TheFrontiers in endocrinology · 2023
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jia SongState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.ORCID 0000-0002-5972-704X
Yao LuState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Xiaoxia ChengKey Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Chuang ShiState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Qiyong LouState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Xia JinState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Jiangyan HeState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Gang ZhaiState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Zhan YinState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Chinese Academy of Sciences · CNHenan University · CN

Funding

Key Science and Technology Program of Henan Province 212102310667National Key Research and Development Program of China 2018YFD0900205National Natural Science Foundation of China 31530077National Natural Science Foundation of China 31972779State Key Laboratory of Freshwater Ecology and Biotechnology 2019FBZ05
6 · The paper itself

Abstract

The hypothalamic-pituitary-thyroid (HPT) axis regulates many critical features in vertebrates. Utilizing TALENs and CRISPR/Cas9 techniques, thyroid-stimulating hormone subunit beta a (

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBase SequenceGoiterHypothyroidismLarvaMonocarboxylic Acid TransportersMorphogenesisMutationPhenotypeReproductionThyroglobulinThyrotropin, beta SubunitTriiodothyronineZebrafishZebrafish ProteinsMonocarboxylic Acid TransportersSlc16a2 protein, zebrafishThyroglobulinThyrotropin, beta SubunitTriiodothyronineZebrafish Proteinsgoiterlarval-to-juvenile transitionsecondary sex characteristicslc16a2thyroglobulinthyroid-stimulating hormone

Identifiers

PMID34440752
PMCPMC8391828
OpenAlexW3193161436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.