Evidence map›Paper›PMID 34440739›Full record

ArticleCells2021

Comprehensive Omics Analysis of a Novel Small-Molecule Inhibitor of Chemoresistant Oncogenic Signatures in Colorectal Cancer Cell with Antitumor Effects.

Tse-Hung Huang, Ntlotlang Mokgautsi, Yan-Jiun Huang, Alexander T H Wu, Hsu-Shan Huang

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Nobiletin in the modified Yiqi Jianpi Decoction enhances the antitumor activity of CD8The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
  2. Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tse-Hung HuangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
Ntlotlang MokgautsiPh.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.ORCID 0000-0003-2076-9768
Yan-Jiun HuangDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan.
Alexander T H WuTMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-0178-6530
Hsu-Shan HuangPh.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.ORCID 0000-0001-6193-5182
Taipei Medical University · TWTaipei Medical University Hospital · TWMing Chi University of Technology · TW

Funding

Ministry of Science and Technology, Taiwan MOST110-2314-B-038-120
6 · The paper itself

Abstract

Tumor recurrence from cancer stem cells (CSCs) and metastasis often occur post-treatment in colorectal cancer (CRC), leading to chemoresistance and resistance to targeted therapy.

Indexed as

AcrylamidesAniline CompoundsAntineoplastic AgentsB7-H1 AntigenBinding SitesCell Line, TumorColorectal NeoplasmsComputational BiologyDrug Resistance, NeoplasmDrug Screening Assays, AntitumorEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHalf-LifeHumansIndolesInterleukin-8AcrylamidesAniline CompoundsAntineoplastic AgentsB7-H1 AntigenCXCL8 protein, humanIndolesInterleukin-8osimertinibProtein Kinase InhibitorsProto-Oncogene Proteins c-mycPyrimidinesTissue Inhibitor of Metalloproteinase-1bioinformaticscancer stem cells (CSCs)chemoresistanceimmune checkpointRV59small molecule

Identifiers

PMID34440739
PMCPMC8392328
OpenAlexW3187123939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.