Evidence map›Paper›PMID 34440736›Full record

ArticleCells2021

A Polymorphism in C-C Chemokine Receptor 5 (CCR5) Associates with Löfgren's Syndrome and Alters Receptor Expression as well as Functional Response.

Bekir Karakaya, Coline H M van Moorsel, Marcel Veltkamp, Claudia Roodenburg-Benschop, Karin M Kazemier, Annette H M van der Helm-van Mil, Tom W J Huizinga, Jan C Grutters, Ger T Rijkers

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Cells · 2022
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bekir KarakayaInterstitial Lung Diseases Centre of Excellence, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands.ORCID 0000-0002-9180-5239
Coline H M van MoorselInterstitial Lung Diseases Centre of Excellence, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands.
Marcel VeltkampInterstitial Lung Diseases Centre of Excellence, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands.
Claudia Roodenburg-BenschopInterstitial Lung Diseases Centre of Excellence, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands.
Karin M KazemierDivision of Heart & Lungs, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Annette H M van der Helm-van MilDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Tom W J HuizingaDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Jan C GruttersInterstitial Lung Diseases Centre of Excellence, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands.
Ger T RijkersDepartment of Science, University College Roosevelt, P.O. Box 94, 4330 AB Middelburg, The Netherlands.ORCID 0000-0001-6948-6123
University Medical Center Utrecht · NLLeiden University Medical Center · NLSt. Antonius Ziekenhuis · NLRoosevelt Institute for American Studies · NL

Funding

ZonMw 842002001
6 · The paper itself

Abstract

C-C chemokine receptor 5 (CCR5) and polymorphisms in

Indexed as

AdultAllelesCalciumCase-Control StudiesChemokine CCL3FemaleGene ExpressionGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMonocytesPolymorphism, Single NucleotideReceptors, CCR5SarcoidosisCalciumCCR5 protein, humanChemokine CCL3Receptors, CCR5calcium influxcalcium kineticsC-C chemokine receptor 5 (CCR5)Löfgren’s syndromesarcoidosissingle nucleotide polymorphism (SNP)

Identifiers

PMID34440736
PMCPMC8394428
OpenAlexW3188170572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.