Evidence map›Paper›PMID 34440724›Full record

ArticleCells2021

Francesco Manfrevola, Bruno Ferraro, Carolina Sellitto, Domenico Rocco, Silvia Fasano, Riccardo Pierantoni, Rosanna Chianese

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Epididymal-Born circRNA Cargo and Its Implications in Male Fertility.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Francesco ManfrevolaDipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.
Bruno FerraroUOSD di Fisiopatologia Della Riproduzione, Presidio Ospedaliero di Marcianise, 81025 Caserta, Italy.
Carolina SellittoUOSD di Fisiopatologia Della Riproduzione, Presidio Ospedaliero di Marcianise, 81025 Caserta, Italy.ORCID 0000-0002-3801-9976
Domenico RoccoDipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.ORCID 0000-0002-6500-1720
Silvia FasanoDipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.
Riccardo PierantoniDipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.
Rosanna ChianeseDipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.ORCID 0000-0003-3631-1794
University of Campania "Luigi Vanvitelli" · ITPresidio Ospedaliero · IT

Funding

Italian Ministry of University and Research Grant PRIN to R. Pierantoni 2017Università degli Studi della Campania Luigi Vanvitelli Grant Dip. Medicina Sperimentale-2020 to R. ChianeseUniversità degli Studi della Campania Luigi Vanvitelli Grant VALERE, Vanvitelli per la Ricerca 2019 to G. Cobellis
6 · The paper itself

Abstract

The etiology of human asthenozoospermia is multifactorial. The need to unveil molecular mechanisms underlying this state of infertility is, thus, impelling. Circular RNAs (circRNAs) are involved in microRNA (miRNA) inhibition by a sponge activity to protect mRNA targets. All together they form the competitive endogenous RNA network (ceRNET). Recently, we have identified differentially expressed circRNAs (DE-circRNAs) in normozoospermic and asthenozoospermic patients, associated with high-quality (A-spermatozoa) and low-quality (B-spermatozoa) sperm. Here, we carried out a differential analysis of

Indexed as

AdultAmino AcidsAsthenozoospermiaCalcium ChannelsCase-Control StudiesCell Adhesion MoleculesDietary SupplementsGene Expression Regulation, DevelopmentalHumansMaleMembrane ProteinsMicroRNAsRNA, CircularSemenSpermatozoaSperm MotilityAmino AcidsCalcium ChannelsCATSPER1 protein, humanCell Adhesion MoleculesCRISP2 protein, humanMembrane ProteinsMicroRNAsPATE1 protein, humanRNA, CircularasthenozoospermiacircRNAsmRNAssperm motilitysperm quality

Identifiers

PMID34440724
PMCPMC8391270
OpenAlexW3189388699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.