Evidence map›Paper›PMID 34440669›Full record

ArticleCells2021

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients.

Dickson W L Wong, Barbara M Klinkhammer, Sonja Djudjaj, Sophia Villwock, M Cherelle Timm, Eva M Buhl, Sophie Wucherpfennig, Claudio Cacchi, Till Braunschweig, Ruth Knüchel-Clarke and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. COVID-19-Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  2. Pooled it
  3. Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. A survey of SARS-CoV-2 tropism.Infectious diseases & immunity · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Translating insights into therapies for Long Covid.Science translational medicine · 2024
    Review
  13. Article
  14. Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. SARS-CoV-2 infection and its effects on the endocrine system.Best practice & research. Clinical endocrinology & metabolism · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Dickson W L WongInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0002-4798-2908
Barbara M KlinkhammerInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0002-1566-7129
Sonja DjudjajInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Sophia VillwockInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
M Cherelle TimmInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Eva M BuhlInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0003-0627-9228
Sophie WucherpfennigInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Claudio CacchiInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Till BraunschweigInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0001-9166-2912
Ruth Knüchel-ClarkeInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0002-4987-701X
Danny JonigkInstitute of Pathology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-5251-2281
Christopher WerleinMember of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 30625 Hannover, Germany.
Roman D BülowInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Edgar DahlInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0002-8439-7994
Saskia von StillfriedInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Peter BoorInstitute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0001-9921-4284
RWTH Aachen University · DEGerman Center for Lung Research · DEMedizinische Hochschule Hannover · DE

Funding

Bundesministerium für Bildung und Forschung 01KX2021Bundesministerium für Bildung und Forschung DEFEAT PANDEMICsBundesministerium für Bildung und Forschung STOP-FSGS-01GM1901ABundesministerium für Gesundheit ZMVI1-2520COR201Deutsche Forschungsgemeinschaft 322900939Deutsche Forschungsgemeinschaft 432698239Deutsche Forschungsgemeinschaft 454024652European Research Council 771883H2020 European Research Council 101001791Medizinische Fakultät, RWTH Aachen University 109/20Medizinische Fakultät, RWTH Aachen University 125/17
6 · The paper itself

Abstract

Multiorgan tropism of SARS-CoV-2 has previously been shown for several major organs. We have comprehensively analyzed 25 different formalin-fixed paraffin-embedded (FFPE) tissues/organs from autopsies of fatal COVID-19 cases (

Indexed as

AgedAngiotensin-Converting Enzyme 2AutopsyCOVID-19Endothelial CellsFemaleGene Expression RegulationHumansMaleMiddle AgedOrgan SpecificityRNA, ViralSARS-CoV-2Serine EndopeptidasesTropismAngiotensin-Converting Enzyme 2RNA, ViralSerine EndopeptidasesTMPRSS2 protein, humanACE2formalin-fixed paraffin-embedded (FFPE) tissuehistologypost-mortemSARS-CoV-2TMPRSS2

Identifiers

PMID34440669
PMCPMC8394956
OpenAlexW3185563492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.