Evidence map›Paper›PMID 34440664›Full record

ArticleCells2021

Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells.

Chieko Hirota, Yui Takashina, Yuta Yoshino, Hajime Hasegawa, Ema Okamoto, Toshiyuki Matsunaga, Akira Ikari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. A lipid atlas of the human kidney.Science advances · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chieko HirotaLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Yui TakashinaLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Yuta YoshinoLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Hajime HasegawaSaitama Medical Center, Department of Nephrology and Hypertension, Saitama Medical University, Saitama 350-8550, Japan.ORCID 0000-0001-7322-912X
Ema OkamotoLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Toshiyuki MatsunagaEducation Center of Green Pharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 502-8585, Japan.
Akira IkariLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.ORCID 0000-0003-2696-0897
Gifu Pharmaceutical University · JPSocial Insurance Saitama Chuo Hospital · JP

Funding

Japan Society for the Promotion of Science 19H03373Kidney Foundation JKFB19-12Public Foundation of Elizabeth Arnold-Fuji AI
6 · The paper itself

Abstract

backgroundA low level of serum magnesium ion (Mg

methodsThe expression of Mg

resultsThe mRNA level of transient receptor potential melastatin 6 (TRPM6), which functions as Mg

conclusionsWe suggest that GA decreases TRPM6 expression mediated by the elevation of ROS and miR-24-3p in renal tubular epithelial cells of T2D.

Indexed as

Oxidative StressAnimalsCell LineDiabetes Mellitus, Type 2Down-RegulationEpithelial CellsGlycated Serum AlbuminGlycation End Products, AdvancedHydrogen PeroxideInsulinKidney Tubules, DistalMagnesiumMicroRNAsRatsReactive Oxygen SpeciesRNA, MessengerGlycated Serum AlbuminGlycation End Products, AdvancedHydrogen PeroxideInsulinMagnesiumMicroRNAsMIRN24 microRNA, ratReactive Oxygen SpeciesRNA, MessengerSerum AlbuminTRPM6 protein, ratTRPM Cation Channelsglycated albuminhypomagnesemiamiRNATRPM6type 2 diabetes mellites

Identifiers

PMID34440664
PMCPMC8393788
OpenAlexW3184233773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.