Evidence map›Paper›PMID 34440497›Full record

ReviewLife (Basel, Switzerland)2021

Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review.

Anna Starshinova, Anna Malkova, Ulia Zinchenko, Dmitry Kudlay, Anzhela Glushkova, Irina Dovgalyk, Piotr Yablonskiy, Yehuda Shoenfeld

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. COVID-19 Vaccines: An Updated Overview of Different Platforms.Bioengineering (Basel, Switzerland) · 2022
    Review
  7. Article
  8. The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Anna StarshinovaAlmazov National Medical Research Centre, Head of the Research Department, 2 Akkuratov Str., 197341 Saint-Petersburg, Russia.
Anna MalkovaMedical Department, Saint Petersburg State University, 199034 Saint-Petersburg, Russia.ORCID 0000-0002-6008-1354
Ulia ZinchenkoSt. Petersburg Research Institute of Phthisiopulmonology, 199034 Saint-Petersburg, Russia.ORCID 0000-0002-6273-4304
Dmitry KudlayNRC Institute of Immunology FMBA of Russia, 115478 Moscow, Russia.ORCID 0000-0003-1878-4467
Anzhela GlushkovaV.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, 192019 Saint Petersburg, Russia.
Irina DovgalykSt. Petersburg Research Institute of Phthisiopulmonology, 199034 Saint-Petersburg, Russia.
Piotr YablonskiyMedical Department, Saint Petersburg State University, 199034 Saint-Petersburg, Russia.
Yehuda ShoenfeldMedical Department, Saint Petersburg State University, 199034 Saint-Petersburg, Russia.
St Petersburg University · RUSaint-Petersburg Research Institute of Phthisiopulmonology · RUFederal Almazov North-West Medical Research Centre · RUSechenov University · RUSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new coronavirus disease (COVID-19) has already affected millions of people in 213 countries. The possibilities of treatment have been reviewed in recent publications but there are many controversial results and conclusions. An analysis of the studies did not reveal a difference in mortality level between people treated with standard therapy, such as antiviral drugs and dexamethasone, and new antiviral drugs/additional immune therapy. However, most studies describe clinical improvement and a decrease in mortality among patients with severe and critical conditions, with the early initiation of additional immune therapy. Possible new targets based on viral life cycles were considered. Unfortunately, the data analysis on the efficacy of different medicine and therapy regimens among patients with COVID-19, showed little success in decreasing the mortality rate in all treatment methods. Some efficacy has been shown with an immunosuppressive therapy in small patient samples, but when a larger number of patients were analyzed the data did not differ significantly from the control groups.

Indexed as

antiviral therapycoronavirus infectionCOVID-19cytokinesimmune therapyintravenous immunoglobulin IgGplasmaSARS-CoV-2

Identifiers

PMID34440497
PMCPMC8400016
OpenAlexW3183679099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.