Evidence map›Paper›PMID 34440479›Full record

ArticleLife (Basel, Switzerland)2021

In-Hospital Mortality of COVID-19 Patients Treated with High-Flow Nasal Oxygen: Evaluation of Biomarkers and Development of the Novel Risk Score Model CROW-65.

Toni Kljakovic Gaspic, Mirela Pavicic Ivelja, Marko Kumric, Andrija Matetic, Nikola Delic, Ivana Vrkic, Josko Bozic

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Effectiveness of high-flow nasal cannula therapy on clinical outcomes in adults with COVID-19: A systematic review.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Toni Kljakovic GaspicDepartment of Anesthesiology and Intensive Medicine, University Hospital of Split, 21000 Split, Croatia.
Mirela Pavicic IveljaDepartment of Infectious Diseases, University Hospital of Split, 21000 Split, Croatia.ORCID 0000-0002-8878-7164
Marko KumricDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0002-9696-3359
Andrija MateticDepartment of Cardiology, University Hospital of Split, 21000 Split, Croatia.ORCID 0000-0001-9272-6906
Nikola DelicDepartment of Anesthesiology and Intensive Medicine, University Hospital of Split, 21000 Split, Croatia.
Ivana VrkicDepartment of Infectious Diseases, University Hospital of Split, 21000 Split, Croatia.
Josko BozicDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0003-1634-0635
University of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To replace mechanical ventilation (MV), which represents the cornerstone therapy in severe COVID-19 cases, high-flow nasal oxygen (HFNO) therapy has recently emerged as a less-invasive therapeutic possibility for those patients. Respecting the risk of MV delay as a result of HFNO use, we aimed to evaluate which parameters could determine the risk of in-hospital mortality in HFNO-treated COVID-19 patients. This single-center cohort study included 102 COVID-19-positive patients treated with HFNO. Standard therapeutic methods and up-to-date protocols were used. Patients who underwent a fatal event (41.2%) were significantly older, mostly male patients, and had higher comorbidity burdens measured by CCI. In a univariate analysis, older age, shorter HFNO duration, ventilator initiation, higher CCI and lower ROX index all emerged as significant predictors of adverse events (

Indexed as

COVID-19HFNOin-hospital outcomesmechanical ventilationrisk scores

Identifiers

PMID34440479
PMCPMC8399648
OpenAlexW3185872691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.