siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference.

Zhiming Fang, Zhongming Zhao, Valsamma Eapen, Raymond A Clarke

Open access · goldAbstract read

In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Transcriptional Interference Regulates the Evolutionary Development of Speech.Genes · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Zhiming FangIngham Institute, School of Psychiatry, University of NSW, Sydney, NSW 2170, Australia.

Zhongming ZhaoCenter for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-3477-0914

Valsamma EapenIngham Institute, School of Psychiatry, University of NSW, Sydney, NSW 2170, Australia.ORCID 0000-0001-6296-8306

Raymond A ClarkeIngham Institute, School of Psychiatry, University of NSW, Sydney, NSW 2170, Australia.

Ingham Institute · AUThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exogenous siRNAs are commonly used to regulate endogenous gene expression levels for gene function analysis, genotype-phenotype association studies and for gene therapy. Exogenous siRNAs can target mRNAs within the cytosol as well as nascent RNA transcripts within the nucleus, thus complicating siRNA targeting specificity. To highlight challenges in achieving siRNA target specificity, we targeted an overlapping gene set that we found associated with a familial form of multiple synostosis syndrome type 4 (SYSN4). In the affected family, we found that a previously unknown non-coding gene

Indexed as

Enhancer Elements, GeneticGene Expression RegulationGene SilencingGene TargetingGrowth Differentiation Factor 6HumansPhenotypeProteinsRNA, AntisenseRNA, Double-StrandedRNA InterferenceRNA, MessengerRNA, Small InterferingSynostosisTranscription, GeneticCFAP418 protein, humanGDF6 protein, humanGrowth Differentiation Factor 6ProteinsRNA, AntisenseRNA, Double-StrandedRNA, MessengerRNA, Small InterferinglncRNAmultiple synostosis syndrome type 4 (SYNS4)sets of interacting transcription units (SITRUS)siRNAtranscriptional interference

Identifiers

PMID34440463

DOI10.3390/genes12081290

PMCPMC8393430

OpenAlexW3193357154

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.