Evidence map›Paper›PMID 34440433›Full record

ArticleGenes2021

Genetic Variations Associated with Long-Term Treatment Response in Bipolar Depression.

Gerard Anmella, Silvia Vilches, Jordi Espadaler-Mazo, Andrea Murru, Isabella Pacchiarotti, Miquel Tuson, Marina Garriga, Eva Solé, Mercè Brat, Giovanna Fico and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Gerard AnmellaBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.ORCID 0000-0002-6798-4054
Silvia VilchesAB-Biotics, S.A., Av. de la Torre Blanca 57, 08172 Sant Cugat del Valles, Barcelona, Catalonia, Spain.ORCID 0000-0003-1070-5533
Jordi Espadaler-MazoAB-Biotics, S.A., Av. de la Torre Blanca 57, 08172 Sant Cugat del Valles, Barcelona, Catalonia, Spain.
Andrea MurruBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.
Isabella PacchiarottiBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.
Miquel TusonAB-Biotics, S.A., Av. de la Torre Blanca 57, 08172 Sant Cugat del Valles, Barcelona, Catalonia, Spain.
Marina GarrigaBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.
Eva SoléBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.
Mercè BratBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.
Giovanna FicoBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.
Eduard VietaBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Catalonia, Spain.ORCID 0000-0002-0548-0053
Centro de Investigación Biomédica en Red de Salud Mental · ESAB-Biotics (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several pharmacogenetic-based decision support tools for psychoactive medication selection are available. However, the scientific evidence of the gene-drug pairs analyzed is mainly based on pharmacogenetic studies in patients with major depression or schizophrenia, and their clinical utility is mostly assessed in major depression. This study aimed at evaluating the impact of individual genes, with pharmacogenetic relevance in other psychiatric conditions, in the response to treatment in bipolar depression. Seventy-six patients diagnosed with bipolar disorder and an index major depressive episode were included in an observational retrospective study. Sociodemographic and clinical data were collected, and all patients were genotyped using a commercial multigene pharmacogenomic-based tool (Neuropharmagen

Indexed as

PharmacogeneticsAdultAge of OnsetAntidepressive AgentsATP Binding Cassette Transporter, Subfamily BBiomarkers, PharmacologicalBipolar DisorderCytochrome P-450 CYP3AFemaleGenetic VariationHumansMaleMiddle AgedPrecision MedicineSelective Serotonin Reuptake InhibitorsTOR Serine-Threonine KinasesABCB1 protein, humanAntidepressive AgentsATP Binding Cassette Transporter, Subfamily BBiomarkers, PharmacologicalCytochrome P-450 CYP3AMTOR protein, humanSelective Serotonin Reuptake InhibitorsTOR Serine-Threonine Kinasesbipolar disordergenetic variantspharmacogeneticsprecision medicinepsychiatric disorderstreatment response

Identifiers

PMID34440433
PMCPMC8391230
OpenAlexW3193624295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.