Evidence map›Paper›PMID 34440368›Full record

ArticleGenes2021

Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.

Olivia Burt, Keira J A Johnston, Nicholas Graham, Breda Cullen, Donald M Lyall, Laura M Lyall, Jill P Pell, Joey Ward, Daniel J Smith, Rona J Strawbridge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olivia BurtInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Keira J A JohnstonInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Nicholas GrahamInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Breda CullenInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Donald M LyallInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Laura M LyallInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Jill P PellInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Joey WardInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Daniel J SmithInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.
Rona J StrawbridgeInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0001-8506-3585

Funding

British Heart FoundationMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/S003061/1
6 · The paper itself

Abstract

backgroundThe link between cardiometabolic and psychiatric illness has long been attributed to human behaviour, however recent research highlights shared biological mechanisms. The

methodsBaseline questionnaire, assessment and genetic data of 402111 unrelated white British ancestry individuals from the UK Biobank was analysed. Genetic association analyses were conducted using PLINK 1.07, assuming an additive genetic model and adjusting for age, sex, genotyping chip, and population structure. Conditional analyses and linkage disequilibrium assessment were used to determine whether cardiometabolic and psychiatric signals were independent.

resultsAssociations between genetic variants in the ASTN2 locus and blood pressure, total and central obesity, neuroticism, anhedonia and mood instability were identified. All analyses support the independence of the cardiometabolic traits from the psychiatric traits. In silico analyses provide support for the central obesity signal acting through

conclusionsOur systematic analysis demonstrates that

Indexed as

Genetic PleiotropyGenetic VariationBlood PressureCardiovascular DiseasesGlycoproteinsHumansLinkage DisequilibriumMental DisordersMetabolic DiseasesNerve Tissue ProteinsASTN2 protein, humanGlycoproteinsNerve Tissue ProteinsanhedoniaASTN2blood pressureBMIcardiovascular diseasecentral obesitymetabolic diseasemood instabilityneuroticismpsychiatric illness

Identifiers

PMID34440368
PMCPMC8391428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.