Evidence map›Paper›PMID 34440333›Full record

ArticleGenes2021

Genotype Pattern Mining for Pairs of Interacting Variants Underlying Digenic Traits.

Atsuko Okazaki, Sukanya Horpaopan, Qingrun Zhang, Matthew Randesi, Jurg Ott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Overview of frequent pattern mining.Genomics & informatics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Atsuko OkazakiDepartment of Diagnostics and Therapeutics of Intractable Diseases, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.
Sukanya HorpaopanDepartment of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
Qingrun ZhangDepartment of Mathematics and Statistics, University of Calgary, Calgary, AB T2N 1N4, Canada.
Matthew RandesiLaboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10065, USA.
Jurg OttLaboratory of Statistical Genetics, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0002-6188-1388
Rockefeller University · USJuntendo University · JPNaresuan University · THUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some genetic diseases ("digenic traits") are due to the interaction between two DNA variants, which presumably reflects biochemical interactions. For example, certain forms of Retinitis Pigmentosa, a type of blindness, occur in the presence of two mutant variants, one each in the

Indexed as

Data MiningGenotypeCase-Control StudiesDatasets as TopicDNAGenetic Diseases, InbornHumansPolymorphism, Single NucleotideDNAdigenic traitsdiplotypegenotype patternpattern mining

Identifiers

PMID34440333
PMCPMC8391494
OpenAlexW3183918753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.