Evidence map›Paper›PMID 34440289›Full record

ArticleGenes2021

DNA Methylation Alterations in Blood Cells of Toddlers with Down Syndrome.

Oxana Yu Naumova, Rebecca Lipschutz, Sergey Yu Rychkov, Olga V Zhukova, Elena L Grigorenko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Oxana Yu NaumovaVavilov Institute of General Genetics RAS, 119991 Moscow, Russia.ORCID 0000-0003-0889-526X
Rebecca LipschutzDepartment of Psychology, University of Houston, Houston, TX 77204, USA.
Sergey Yu RychkovVavilov Institute of General Genetics RAS, 119991 Moscow, Russia.
Olga V ZhukovaVavilov Institute of General Genetics RAS, 119991 Moscow, Russia.
Elena L GrigorenkoDepartment of Psychology, University of Houston, Houston, TX 77204, USA.
Vavilov Institute of General Genetics · RUSt Petersburg University · RUUniversity of Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent research has provided evidence on genome-wide alterations in DNA methylation patterns due to trisomy 21, which have been detected in various tissues of individuals with Down syndrome (DS) across different developmental stages. Here, we report new data on the systematic genome-wide DNA methylation perturbations in blood cells of individuals with DS from a previously understudied age group-young children. We show that the study findings are highly consistent with those from the prior literature. In addition, utilizing relevant published data from two other developmental stages, neonatal and adult, we track a quasi-longitudinal trend in the DS-associated DNA methylation patterns as a systematic epigenomic destabilization with age.

Indexed as

DNA MethylationChild, PreschoolDown SyndromeFemaleHumansMaleDNA methylationDown syndromeIllumina 450K Human Methylation Arrayinfants and toddlerstrisomy 21

Identifiers

PMID34440289
PMCPMC8391316
OpenAlexW3183416871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.