Evidence map›Paper›PMID 34440275›Full record

ArticleBiomedicines2021

Diffusion Weighted Imaging and T2 Mapping Detect Inflammatory Response in the Renal Tissue during Ischemia Induced Acute Kidney Injury in Different Mouse Strains and Predict Renal Outcome.

Robert Greite, Katja Derlin, Dagmar Hartung, Rongjun Chen, Martin Meier, Marcel Gutberlet, Bennet Hensen, Frank Wacker, Faikah Gueler, Susanne Hellms

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Ultrafast and robustMagnetic resonance in medicine · 2025
    Article
  7. Article
  8. Assessment of Acute Kidney Injury using MRI.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert GreiteNephrology, Hannover Medical School, 30625 Hannover, Germany.
Katja DerlinRadiology, Hannover Medical School, 30625 Hannover, Germany.
Dagmar HartungRadiology, Hannover Medical School, 30625 Hannover, Germany.
Rongjun ChenNephrology, Hannover Medical School, 30625 Hannover, Germany.
Martin MeierLaboratory Animal Science, Hannover Medical School, 30625 Hannover, Germany.
Marcel GutberletRadiology, Hannover Medical School, 30625 Hannover, Germany.
Bennet HensenRadiology, Hannover Medical School, 30625 Hannover, Germany.
Frank WackerRadiology, Hannover Medical School, 30625 Hannover, Germany.
Faikah GuelerNephrology, Hannover Medical School, 30625 Hannover, Germany.
Susanne HellmsRadiology, Hannover Medical School, 30625 Hannover, Germany.

Funding

Deutsche Forschungsgemeinschaft GU613/1-1, HU2232/1Medizinischen Hochschule Hannover Young faculty program
6 · The paper itself

Abstract

To characterize ischemia reperfusion injury (IRI)-induced acute kidney injury (AKI) in C57BL/6 (B6) and CD1-mice by longitudinal functional MRI-measurement of edema formation (T2-mapping) and inflammation (diffusion weighted imaging (DWI)). IRI was induced with unilateral right renal pedicle clamping for 35min. 7T-MRI was performed 1 and 14 days after surgery. DWI (7 b-values) and multiecho TSE sequences (7 TE) were acquired. Parameters were quantified in relation to the contralateral kidney on day 1 (d1). Renal MCP-1 and IL-6-levels were measured by qPCR and serum-CXCL13 by ELISA. Immunohistochemistry for fibronectin and collagen-4 was performed. T2-increase on d1 was higher in the renal cortex (127 ± 5% vs. 94 ± 6%,

Indexed as

acute kidney injurydiffusion weighted imagingfunctional MRIischemia reperfusion injuryT2 mapping

Identifiers

PMID34440275
PMCPMC8393575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.