ArticleBiomedicines2021
Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic models in COVID-19 infection that predict severity: a systematic review.European journal of epidemiology · 2023Pooled it
- The Use of the Rox Index to Guide High-Flow Nasal Cannula Therapy and the Need for Intubation Is Associated With Meaningful Patient Outcomes.CHEST critical care · 2026Article
- Explainable artificial intelligence for predicting cardiovascular events in hospitalised COVID-19 patients.BMC infectious diseases · 2025Article
- Non-invasive SpO2/FiO2 ratio (SFR) as surrogate for PaO2/FiO2 ratio (PFR): A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Review
- Evaluation of physiological severity scores for predicting COVID-19 disease progression: a retrospective study.BMC infectious diseases · 2025Article
- Severe COVID-19 in Non-Smokers: Predictive Factors and Outcomes.Healthcare (Basel, Switzerland) · 2025Article
- SpOBiomedicines · 2025Article
- Unraveling relevant cross-waves pattern drifts in patient-hospital risk factors among hospitalized COVID-19 patients using explainable machine learning methods.BMC infectious diseases · 2025Article
- The SpOJournal of clinical medicine · 2024Article
- Comparison of modified quick Sequential Organ Failure Assessment models as triage tools for febrile patients.Clinical and experimental emergency medicine · 2024Article
- Predictors of high-flow nasal cannula failure in COVID-19 patients in a northern Peruvian hospital.BMC pulmonary medicine · 2024Article
- Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19.Annals of intensive care · 2024Article
- Performance of oxygenation indices and risk scores to predict invasive mechanical ventilation and mortality in COVID-19.BMC pulmonary medicine · 2024Article
- ROX index performance to predict high-flow nasal oxygen outcome in Covid-19 related hypoxemic acute respiratory failure.Annals of intensive care · 2024Article
- Article
- Factors Associated with COVID-19 Death in a High-Altitude Peruvian Setting during the First 14 Months of the Pandemic: A Retrospective Multicenter Cohort Study in Hospitalized Patients.Tropical medicine and infectious disease · 2023Article
- Non-invasive respiratory support in the management of COVID-19: a synthesis of systematic reviews.British journal of cardiac nursing · 2023Article
- Article
- Clinical Findings and Outcomes From Subjects With COVID-19 Pneumonia in an Intermediate Respiratory Care Unit.Respiratory care · 2023Observational
- Predictive Factors of Oxygen Therapy Failure in Patients with COVID-19 in the Emergency Department.Open access emergency medicine : OAEM · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The ability of COVID-19 to compromise the respiratory system has generated a substantial proportion of critically ill patients in need of invasive mechanical ventilation (IMV). The objective of this paper was to analyze the prognostic ability of the pulse oximetry saturation/fraction of inspired oxygen ratio (SpO2/FiO2) and the ratio of SpO2/FiO2 to the respiratory rate-ROX index-as predictors of IMV in an emergency department in confirmed COVID-19 patients. A multicenter, retrospective cohort study was carried out in four provinces of Spain between March and November 2020. The discriminative power of the predictive variable was assessed through a prediction model trained using a derivation sub-cohort and evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) on the validation sub-cohort. A total of 2040 patients were included in the study. The IMV rate was 10.1%, with an in-hospital mortality rate of 35.3%. The performance of the SpO2/FiO2 ratio was better than the ROX index-AUC = 0.801 (95% CI 0.746-0.855) and AUC = 0.725 (95% CI 0.652-0.798), respectively. In fact, a direct comparison between AUCs resulted in significant differences (
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