Evidence map›Paper›PMID 34440202›Full record

ArticleBiomedicines2021

Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization.

Konstantin A Toniyan, Victoria V Povorova, Elena Yu Gorbacheva, Valery V Boyarintsev, Irina V Ogneva

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Konstantin A ToniyanGynecology Department, FGBU KB1 (Volynskaya) UDP RF, 121352 Moscow, Russia.
Victoria V PovorovaGynecology Department, FGBU KB1 (Volynskaya) UDP RF, 121352 Moscow, Russia.
Elena Yu GorbachevaGynecology Department, FGBU KB1 (Volynskaya) UDP RF, 121352 Moscow, Russia.
Valery V BoyarintsevEmergency and Extreme Medicine Department, FGBU DPO CGMA UDP RF, 121359 Moscow, Russia.
Irina V OgnevaCell Biophysics Laboratory, SSC RF-IBMP RAS, 123007 Moscow, Russia.ORCID 0000-0003-0125-5876

Funding

program for fundamental research SSC RF - IBMP RAS 65.4Strategic Academic Leadership Program Sechenov University
6 · The paper itself

Abstract

(1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton. In this study, we describe two clinical cases involving rare localization of extragenital endometriosis (umbilicus) and compare them with genital endometriosis of different localization (ovaries and uterus), as well as eutopic endometrium obtained with separate diagnostic curettage without confirmed pathology. (2) Methods: The relative content of actin and tubulin cytoskeleton proteins was determined by Western blotting, and the expression of genes encoding these proteins was determined by RT-PCR in the obtained intraoperative biopsies. The content of 5hmC was estimated by dot blot experiments, and the methylase/demethylase and acetylase/deacetylase contents were determined. (3) Results: The obtained results indicate that the content of the actin-binding protein alpha-actinin1 significantly increased (

Indexed as

cell motilitycytoskeletonendometriosismicrofilamenttubulin

Identifiers

PMID34440202
PMCPMC8394853

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.