Evidence map›Paper›PMID 34440177›Full record

ArticleBiomedicines2021

Hepatic and Extrahepatic Insulin Clearance in Mice with Double Deletion of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Receptors.

Micaela Morettini, Agnese Piersanti, Laura Burattini, Giovanni Pacini, Christian Göbl, Bo Ahrén, Andrea Tura

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Micaela MorettiniDepartment of Information Engineering, Università Politecnica delle Marche, 60131 Ancona, Italy.ORCID 0000-0002-8327-8379
Agnese PiersantiDepartment of Information Engineering, Università Politecnica delle Marche, 60131 Ancona, Italy.
Laura BurattiniDepartment of Information Engineering, Università Politecnica delle Marche, 60131 Ancona, Italy.ORCID 0000-0002-9474-7046
Giovanni PaciniIndependent Researcher, 35142 Padova, Italy.
Christian GöblDepartment of Obstetrics and Gynecology, Medical University of Vienna, A-1090 Vienna, Austria.
Bo AhrénDepartment of Clinical Sciences, Lund University, 221 84 Lund, Sweden.
Andrea TuraMetabolic Unit, CNR Institute of Neuroscience, 35127 Padova, Italy.

Funding

Lund University Medical FacultyRegion SkåneSwedish Research Council 6834
6 · The paper itself

Abstract

The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild-type (WT) mice, which underwent an Intravenous Glucose Tolerance Test (IVGTT). A novel methodology based on mathematical modeling was designed to provide two sets of values (FE

Indexed as

animal modelDIRKOincretin hormonesinsulin clearanceIVGTTmathematical model

Identifiers

PMID34440177
PMCPMC8393926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.