Evidence map›Paper›PMID 34440166›Full record

ArticleBiomedicines2021

In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution.

Suresh Kumar, Johannes Koenig, Andreas Schneider, Fredrik Wermeling, Sanjaykumar Boddul, Sebastian J Theobald, Miriam Vollmer, Doreen Kloos, Nico Lachmann, Frank Klawonn and 7 more

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Suresh KumarLaboratory of Regenerative Immune Therapies Applied, REBIRTH-Research Center for Translational Regenerative Medicine, D-30625 Hannover, Germany.
Johannes KoenigLaboratory of Regenerative Immune Therapies Applied, REBIRTH-Research Center for Translational Regenerative Medicine, D-30625 Hannover, Germany.ORCID 0000-0002-2018-9125
Andreas SchneiderLaboratory of Regenerative Immune Therapies Applied, REBIRTH-Research Center for Translational Regenerative Medicine, D-30625 Hannover, Germany.
Fredrik WermelingDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institute, 17177 Solna, Sweden.
Sanjaykumar BoddulDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institute, 17177 Solna, Sweden.
Sebastian J TheobaldDepartment of Internal Medicine I, Faculty of Medicine and University Hospital of Cologne, University of Cologne, D-50924 Cologne, Germany.
Miriam VollmerLaboratory of Regenerative Immune Therapies Applied, REBIRTH-Research Center for Translational Regenerative Medicine, D-30625 Hannover, Germany.
Doreen KloosInstitute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.
Nico LachmannDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, D-30625 Hannover, Germany.ORCID 0000-0002-4245-1497
Frank KlawonnBiostatistics Group, Helmholtz Centre for Infection Research, D-38124 Braunschweig, Germany.ORCID 0000-0001-9613-182X
Stefan LienenklausInstitute for Laboratory Animal Science, Hannover Medical School, D-30625 Hannover, Germany.ORCID 0000-0003-4790-3445
Steven R TalbotInstitute for Laboratory Animal Science, Hannover Medical School, D-30625 Hannover, Germany.ORCID 0000-0002-9062-4065
André BleichInstitute for Laboratory Animal Science, Hannover Medical School, D-30625 Hannover, Germany.
Nadine WenzelInstitute for Transfusion Medicine and Transplant Engineering, Hannover Medical School, D-30625 Hannover, Germany.
Constantin von KaisenbergDepartment of Obstetrics, Gynecology and Reproductive Medicine, Hannover Medical School, D-30625 Hannover, Germany.
James KeckThe Jackson Laboratory, Sacramento, CA 95838, USA.
Renata StripeckeLaboratory of Regenerative Immune Therapies Applied, REBIRTH-Research Center for Translational Regenerative Medicine, D-30625 Hannover, Germany.ORCID 0000-0001-7756-8460

Funding

Deutsches Zentrum für Infektionsforschung DZIF-TTU07.805Jackson Laboratory LV/HLA
6 · The paper itself

Abstract

Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the human immune system (HIS-mice) are invigorating preclinical testing of vaccines and immunotherapies. We have recently shown that human engineered dendritic cells boosted

Indexed as

B cell maturationclass-switchcytomegalovirusHLA matchhumanized miceIgGlentiviral vectorstem cell transplantationvaccine

Identifiers

PMID34440166
PMCPMC8393476

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.