Evidence map›Paper›PMID 34440159›Full record

ArticleBiomedicines2021

Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity.

Dimitris Matiadis, See-Ting Ng, Eric H-L Chen, Georgia Nigianni, Veroniki P Vidali, Aleksander Canko, Rita P-Y Chen, Marina Sagnou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dimitris MatiadisNCSR "Demokritos", Institute of Biosciences and Applications, Patr. Grigoriou and Neapoleos 27, 153 41 Athens, Greece.ORCID 0000-0003-0059-952X
See-Ting NgInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd., Nankang, Taipei 115, Taiwan.
Eric H-L ChenInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd., Nankang, Taipei 115, Taiwan.
Georgia NigianniNCSR "Demokritos", Institute of Biosciences and Applications, Patr. Grigoriou and Neapoleos 27, 153 41 Athens, Greece.
Veroniki P VidaliNCSR "Demokritos", Institute of Nanoscience and Nanotechnology, Patr. Grigoriou and Neapoleos 27, 153 41 Athens, Greece.ORCID 0000-0001-9020-8726
Aleksander CankoNCSR "Demokritos", Institute of Nanoscience and Nanotechnology, Patr. Grigoriou and Neapoleos 27, 153 41 Athens, Greece.
Rita P-Y ChenInstitute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd., Nankang, Taipei 115, Taiwan.ORCID 0000-0003-3987-033X
Marina SagnouNCSR "Demokritos", Institute of Biosciences and Applications, Patr. Grigoriou and Neapoleos 27, 153 41 Athens, Greece.

Funding

Operational Programme "Competitiveness, Entrepreneurship and Innovation" (NSRF 2014-2020) MIS 5002691
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD.

aimsTen hydroxylated monocarbonyl curcumin derivatives were designed, synthesized and evaluated for their NEP upregulating potential using sensitive fluorescence-based Aβ digestion and inhibition assays.

resultsCompound

Indexed as

Alzheimer’s diseaseamyloid cleavageAβ amyloid peptidemonocarbonyl curcumin derivativesneprilysin

Identifiers

PMID34440159
PMCPMC8394082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.