Evidence map›Paper›PMID 34440155›Full record

ArticleBiomedicines2021

Triterpenoid-PEG Ribbons Targeting Selectivity in Pharmacological Effects.

Zulal Özdemir, Uladzimir Bildziukevich, Martina Čapková, Petra Lovecká, Lucie Rárová, David Šaman, Michala Zgarbová, Barbora Lapuníková, Jan Weber, Oxana Kazakova and 1 more

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zulal ÖzdemirDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology in Prague, Technická 5, 16628 Prague 6, Czech Republic.ORCID 0000-0002-9083-4919
Uladzimir BildziukevichDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology in Prague, Technická 5, 16628 Prague 6, Czech Republic.
Martina ČapkováDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology in Prague, Technická 5, 16628 Prague 6, Czech Republic.ORCID 0000-0002-6781-2324
Petra LoveckáDepartment of Biochemistry and Microbiology, University of Chemistry and Technology in Prague, Technická 5, 16628 Prague 6, Czech Republic.
Lucie RárováDepartment of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech Republic.ORCID 0000-0002-3300-007X
David ŠamanInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, 16610 Prague 6, Czech Republic.
Michala ZgarbováInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, 16610 Prague 6, Czech Republic.
Barbora LapuníkováInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, 16610 Prague 6, Czech Republic.
Jan WeberInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, 16610 Prague 6, Czech Republic.
Oxana KazakovaUfa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71, pr. Oktyabrya, 450054 Ufa, Russia.ORCID 0000-0002-5606-1588
Zdeněk WimmerDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology in Prague, Technická 5, 16628 Prague 6, Czech Republic.

Funding

European Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000738Ministerstvo Průmyslu a Obchodu FV30300
6 · The paper itself

Abstract

(1) Background: To compare the effect of selected triterpenoids with their structurally resembling derivatives, designing of the molecular ribbons was targeted to develop compounds with selectivity in their pharmacological effects. (2) Methods: In the synthetic procedures, Huisgen 1,3-dipolar cycloaddition was applied as a key synthetic step for introducing a 1,2,3-triazole ring as a part of a junction unit in the molecular ribbons. (3) Results: The antimicrobial activity, antiviral activity, and cytotoxicity of the prepared compounds were studied. Most of the molecular ribbons showed antimicrobial activity, especially on

Indexed as

amide bondanti-HIV activityantimicrobial activitycytotoxicityHuisgen 1,3-dipolar cycloadditionmolecular ribbonmultifunctional PEG3 derivativesupramolecular self-assemblytriterpenoid

Identifiers

PMID34440155
PMCPMC8391127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.