Evidence map›Paper›PMID 34440147›Full record

ArticleBiomedicines2021

Attention to Face as a Predictor of Developmental Change and Treatment Outcome in Young Children with Autism Spectrum Disorder.

Kenza Latrèche, Nada Kojovic, Martina Franchini, Marie Schaer

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  4. Article
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  6. Article
  7. Article
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  9. Review
  10. Speech Reception in Young Children with Autism Is Selectively Indexed by a Neural Oscillation Coupling Anomaly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. Review
  13. Examining Predictors of Different ABA Treatments: A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kenza LatrècheDepartment of Psychiatry, Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland.
Nada KojovicDepartment of Psychiatry, Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland.ORCID 0000-0003-0116-2485
Martina FranchiniFondation Pôle Autisme, 1204 Geneva, Switzerland.
Marie SchaerDepartment of Psychiatry, Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland.
University of Geneva · CH

Funding

National Center of Competence in Research "Synapsy" 51NF40_185897Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 163859Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 190084
6 · The paper itself

Abstract

The beneficial effect of early intervention is well described for children with autism spectrum disorder (ASD). Response to early intervention is, however, highly heterogeneous in affected children, and there is currently only scarce information about predictors of response to intervention. Based on the hypothesis that impaired social orienting hinders the subsequent development of social communication and interactions in children with ASD, we sought to examine whether the level of social orienting modulates treatment outcome in young children with ASD. We used eye-tracking technology to measure social orienting in a group of 111 preschoolers, comprising 95 young children with ASD and 16 children with typical development, as they watched a 29 s video of a woman engaging in child-directed speech. In line with previous studies, we report that attention to face is robustly correlated with autistic symptoms and cognitive and adaptive skills at baseline. We further leverage longitudinal data in a subgroup of 81 children with ASD and show that the level of social orienting at baseline is a significant predictor of developmental gains and treatment outcome. These results pave the way for identifying subgroups of children who show a better response to early and intensive intervention, a first step toward precision medicine for children with autism.

Indexed as

autism spectrum disordersearly interventioneye-trackingpredictors of treatment outcomesocial attention

Identifiers

PMID34440147
PMCPMC8392329
OpenAlexW3188256068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.