DNA Hypermethylation Involves in the Down-Regulation of Chloride Intracellular Channel 4 (CLIC4) Induced by Photodynamic Therapy.

Pei-Chi Chiang, Pei-Tzu Li, Ming-Jen Lee, Chin-Tin Chen

Abstract read

In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Photodynamic Therapy.Biomedicines · 2022
Article

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Pei-Chi ChiangDepartment of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.

Pei-Tzu LiDepartment of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.

Ming-Jen LeeDepartment of Neurology and Medical Genetics, National Taiwan University Hospital, Taipei 10012, Taiwan.

Chin-Tin ChenDepartment of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0002-7439-8774

Funding

Ministry of Science and Technology, Taiwan NSC 101-2320-B-002-047-MY3, MOST 104-2320-B-002-041, MOST 107-2314-B-002-057

6 · The paper itself

Abstract

The altered expression of chloride intracellular channel 4 (CLIC4) was reported to correlate with tumor progression. Previously, we have shown that the reduced cellular invasion induced by photodynamic therapy (PDT) is associated with suppression of CLIC4 expression in PDT-treated cells. Herein, we attempted to decipher the regulatory mechanisms involved in PDT-mediated CLIC4 suppression in A375 and MDA-MB-231 cells in vitro. We found that PDT can increase the expression and enzymatic activity of DNA methyltransferase 1 (DNMT1). Bisulfite sequencing PCR further revealed that PDT can induce hypermethylation in the

Indexed as

CLIC4DNA methylationoxidative stressPDT

Identifiers

PMID34440131

DOI10.3390/biomedicines9080927

PMCPMC8394338

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