Evidence map›Paper›PMID 34440126›Full record

ArticleBiomedicines2021

Bradykinin, as a Reprogramming Factor, Induces Transdifferentiation of Brain Astrocytes into Neuron-like Cells.

Tsong-Hai Lee, Pei-Shan Liu, Su-Jane Wang, Ming-Ming Tsai, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Activation of Bradykinin BInternational journal of molecular sciences · 2024
    Article
  2. Review
  3. Review
  4. Quercetin exerts anti-inflammatory effectsWorld journal of gastroenterology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tsong-Hai LeeStroke Center and Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan City 33305, Taiwan.
Pei-Shan LiuDepartment of Microbiology, Soochow University, Taipei City 11102, Taiwan.
Su-Jane WangSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Ming-Ming TsaiResearch Center for Chinese Herbal Medicine, Department of Nursing, Division of Basic Medical Sciences, Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan.ORCID 0000-0002-4495-6616
Velayuthaprabhu ShanmugamDepartment of Biotechnology, Bharathiar University, Coimbatore 641046, India.ORCID 0000-0003-3700-1907
Hsi-Lung HsiehResearch Center for Chinese Herbal Medicine, Department of Nursing, Division of Basic Medical Sciences, Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan.ORCID 0000-0001-8302-2472

Funding

Chang Gung Medical Foundation CMRPF1F0132; CMRPF1H0051~3; CMRPF1I0041~2; CMRPF1L0021Chang Gung University of Science and Technology ZRRPF3J0081; ZRRPF3K0111Ministry of Science and Technology, Taiwan MOST107-2320-B-255-003; 108-2320-B-255-002-MY3
6 · The paper itself

Abstract

Kinins are endogenous, biologically active peptides released into the plasma and tissues via the kallikrein-kinin system in several pathophysiological events. Among kinins, bradykinin (BK) is widely distributed in the periphery and brain. Several studies on the neuro-modulatory actions of BK by the B

Indexed as

bradykininbrain astrocytesmatrix metalloproteinase-9reprogramming factortransdifferentiation

Identifiers

PMID34440126
PMCPMC8389672

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.