ReviewBiomedicines2021
Predictive Antibiotic Susceptibility Testing by Next-Generation Sequencing for Periprosthetic Joint Infections: Potential and Limitations.
Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- From Culture to Sequencing: Evolving Strategies for the Diagnosis of Pediatric Spondylodiscitis.Orthopaedic surgery · 2026Review
- The Application of artificial intelligence in periprosthetic joint infection.Journal of advanced research · 2026Review
- Host niche-specific challenges hindering the treatment of polymicrobial infections.Journal of bacteriology · 2025Review
- Precision medicine in Asia enhanced by next-generation sequencing: Implications for Thailand through a scoping review and interview study.Clinical and translational science · 2024Article
- Artificial intelligence in planned orthopaedic care.SICOT-J · 2024Article
- Diagnostic performance of metagenomic next-generation sequencing and conventional microbial culture for spinal infection: a retrospective comparative study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Application of machine learning in the prevention of periprosthetic joint infection following total knee arthroplasty: a systematic review.Arthroplasty (London, England) · 2023Review
- Metagenomic next-generation sequencing in osteoarticular infections with a focus on pediatrics: current concepts and clinical applications.EFORT open reviews · 2023Review
- Global Cluster Analysis and Network Visualization in Prosthetic Joint Infection: A Scientometric Mapping.Orthopaedic surgery · 2023Article
- Advances in the Microbiological Diagnosis of Prosthetic Joint Infections.Diagnostics (Basel, Switzerland) · 2023Review
- Metagenomic Antimicrobial Susceptibility Testing from Simulated Native Patient Samples.Antibiotics (Basel, Switzerland) · 2023Article
- Molecular Approach for the Laboratory Diagnosis of Periprosthetic Joint Infections.Microorganisms · 2022Review
- Automated antimicrobial susceptibility testing and antimicrobial resistance genotyping using Illumina and Oxford Nanopore Technologies sequencing data amongFrontiers in microbiology · 2022Article
- Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Joint replacement surgeries are one of the most frequent medical interventions globally. Infections of prosthetic joints are a major health challenge and typically require prolonged or even indefinite antibiotic treatment. As multidrug-resistant pathogens continue to rise globally, novel diagnostics are critical to ensure appropriate treatment and help with prosthetic joint infections (PJI) management. To this end, recent studies have shown the potential of molecular methods such as next-generation sequencing to complement established phenotypic, culture-based methods. Together with advanced bioinformatics approaches, next-generation sequencing can provide comprehensive information on pathogen identity as well as antimicrobial susceptibility, potentially enabling rapid diagnosis and targeted therapy of PJIs. In this review, we summarize current developments in next generation sequencing based predictive antibiotic susceptibility testing and discuss potential and limitations for common PJI pathogens.
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Registered trials
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